POLD2 explained

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.^{[1] [2]} It is a component of the DNA polymerase delta complex.

Interactions

POLD2 has been shown to interact with PCNA.^[3]

Further reading

• Hindges R, Hübscher U . Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2). . Genomics . 44 . 1 . 45–51 . 1997 . 9286699 . 10.1006/geno.1997.4838 .
• Hisama FM . WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts . Cancer Res. . 60 . 9 . 2372–6 . 2000 . 10811112 . Chen YH . Meyn MS . Oshima . J . Weissman . SM .
• Mo J . Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA . Biochemistry . 39 . 24 . 7245–54 . 2000 . 10852724 . 10.1021/bi0000871 . Liu L . Leon A . Mazloum . Nayef . Lee . Marietta Y. W. T. .
• Perez A, Leon A, Lee MY . Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta . Biochim. Biophys. Acta . 1493 . 1–2 . 231–6 . 2000 . 10978529 . 10.1016/s0167-4781(00)00153-6.
• Szekely AM . Werner protein recruits DNA polymerase δ to the nucleolus . Proc. Natl. Acad. Sci. U.S.A. . 97 . 21 . 11365–70 . 2000 . 11027336 . 10.1073/pnas.97.21.11365 . 17206 . Chen YH . Zhang C . Oshima . J . Weissman . SM . 2000PNAS...9711365S. free .
• He H, Tan CK, Downey KM, So AG . A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen . Proc. Natl. Acad. Sci. U.S.A. . 98 . 21 . 11979–84 . 2001 . 11593007 . 10.1073/pnas.221452098 . 59753 . 2001PNAS...9811979H . free .
• Lu X . Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta . J. Biol. Chem. . 277 . 27 . 24340–5 . 2002 . 11986310 . 10.1074/jbc.M200065200 . Tan CK . Zhou JQ . You . M . Carastro . LM . Downey . KM . So . AG . free .
• Ohta S . A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein . J. Biol. Chem. . 277 . 43 . 40362–7 . 2002 . 12171929 . 10.1074/jbc.M206194200 . Shiomi Y . Sugimoto K . Obuse . C . Tsurimoto . T . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Liu L . Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen . J. Biol. Chem. . 278 . 12 . 10041–7 . 2003 . 12522211 . 10.1074/jbc.M208694200 . Rodriguez-Belmonte EM . Mazloum N . Xie . B . Lee . MY . free.
• Scherer SW . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . Cheung J . MacDonald JR . Osborne . LR . Nakabayashi . K . Herbrick . JA . Carson . AR . Parker-Katiraee . L . Skaug . J . 2003Sci...300..767S.
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Tsurimoto T . Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta . Genes Cells . 10 . 1 . 13–22 . 2005 . 15670210 . 10.1111/j.1365-2443.2004.00812.x . Shinozaki A . Yano M . Seki . Masayuki . Enomoto . Takemi . 24977510 .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R. 4427026 .

Notes and References

1. Zhang J, Tan CK, McMullen B, Downey KM, So AG . Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2) . Genomics . 29 . 1 . 179–86 . Feb 1996 . 8530069 . 10.1006/geno.1995.1229 . free .
2. Web site: Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa.
3. Lu . Xiaoqing . Tan Cheng-Keat . Zhou Jin-Qiu . You Min . Carastro L Michael . Downey Kathleen M . So Antero G . Jul 2002 . Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta . J. Biol. Chem. . 277 . 27 . 24340–5 . United States. 0021-9258. 11986310 . 10.1074/jbc.M200065200 . free .