DNA polymerase alpha subunit 2 explained

DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.^{[1] [2] [3]}

Interactions

POLA2 has been shown to interact with PARP1.^[4]

See also

• DNA Polymerase
• DNA polymerase alpha

Further reading

• Pollok S, Stoepel J, Bauerschmidt C, Kremmer E, Nasheuer HP . Regulation of eukaryotic DNA replication at the initiation step . Biochem. Soc. Trans. . 31 . Pt 1 . 266–9 . 2003 . 12546699 . 10.1042/BST0310266 .
• Nasheuer HP, Moore A, Wahl AF, Wang TS . Cell cycle-dependent phosphorylation of human DNA polymerase alpha . J. Biol. Chem. . 266 . 12 . 7893–903 . 1991 . 10.1016/S0021-9258(20)89534-9 . 1902230 . free .
• Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J . Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication . Nucleic Acids Res. . 26 . 8 . 1891–8 . 1998 . 9518481 . 147507 . 10.1093/nar/26.8.1891 .
• Schneider A, Smith RW, Kautz AR, Weisshart K, Grosse F, Nasheuer HP . Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit . J. Biol. Chem. . 273 . 34 . 21608–15 . 1998 . 9705292 . 10.1074/jbc.273.34.21608 . free .
• Taneja P, Gu J, Peng R, Carrick R, Uchiumi F, Ott RD, Gustafson E, Podust VN, Fanning E . A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication . J. Biol. Chem. . 277 . 43 . 40853–61 . 2002 . 12181327 . 10.1074/jbc.M208067200 . free .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase alpha subunit B

Notes and References

1. Collins KL, Russo AA, Tseng BY, Kelly TJ . The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication . EMBO J . 12 . 12 . 4555–66 . Dec 1993 . 8223465 . 413886 . 10.1002/j.1460-2075.1993.tb06144.x.
2. Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE . E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2 . Nucleic Acids Res . 29 . 13 . 2810–21 . Jul 2001 . 11433027 . 55767 . 10.1093/nar/29.13.2810 .
3. Web site: Entrez Gene: POLA2 polymerase (DNA directed), alpha 2 (70kD subunit).
4. Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J . Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication . Nucleic Acids Res. . 26 . 8 . 1891–8 . Apr 1998 . 9518481 . 147507 . 10.1093/nar/26.8.1891 .