PODXL2 explained

Podocalyxin like 2 is a protein that in humans is encoded by the PODXL2 gene.^[1]

Structure

This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012].

Function

Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins

Further reading

• Fieger CB, Sassetti CM, Rosen SD . Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x . J. Biol. Chem. . 278 . 30 . 27390–8 . 2003 . 12889478 . 10.1074/jbc.M304204200 . free .

Notes and References

1. Web site: Entrez Gene: Podocalyxin like 2. 2017-10-11.