PNU-22394 explained

PNU-22394 is a drug which acts as an agonist at serotonin 5-HT₂ receptors, with strongest binding affinity for 5-HT_2A and 5-HT_2C and slightly weaker at 5-HT_2B, although it is only a full agonist at 5-HT_2C, but partial agonist at 5-HT_2A and 5-HT_2B. It has anorectic effects in both animal studies and human trials,^{[1] [2]} along with "Pro-Cognitive Properties",^[3] although it has never been developed for medical use.

See also

• DM-506
• Lorcaserin
• Tryptoline
• PNU-181731
• PHA-57378
• Tabernanthalog

Notes and References

1. McCall RB, Franklin SR, Hyslop DK, Knauer CS, Chio CL, Haber CL, Fitzgerald LW . PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans . 2001 . Society for Neuroscience --> . Presentation Number 309.2 . 27 . 309.2 . Society for Neuroscience Abstracts . Convention Center Exhibit Hall, Poster Board TT-45, San Diego, CA . Online . 18 July 2014.
2. Garfield AS, Heisler LK . Pharmacological targeting of the serotonergic system for the treatment of obesity . The Journal of Physiology . 587 . 1 . 49–60 . January 2009 . 19029184 . 2670022 . 10.1113/jphysiol.2008.164152 .
3. Jensen AA, Plath N, Pedersen MH, Isberg V, Krall J, Wellendorph P, Stensbøl TB, Gloriam DE, Krogsgaard-Larsen P, Frølund B . 6 . Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties . Journal of Medicinal Chemistry . 56 . 3 . 1211–27 . February 2013 . 23301527 . 10.1021/jm301656h . 10.1.1.691.154 .