PNRC1 explained

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.^{[1] [2]}

Function

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.^{[3] [4]} The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.^[4]

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Zhou D, Chen B, Ye JJ, Chen S . A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction . Oncogene . 23 . 31 . 5394–404 . 2004 . 15122321 . 10.1038/sj.onc.1207695 . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hsiao PW, Chang C . Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells . J. Biol. Chem. . 274 . 32 . 22373–9 . 1999 . 10428808 . 10.1074/jbc.274.32.22373 . 10.1.1.621.2877 . 15532327 . free .

Notes and References

1. Chen J, Liu L, Pohajdak B . Cloning a cDNA from human NK/T cells which codes for a protein with high proline content . Biochim Biophys Acta . 1264 . 1 . 19–22 . Dec 1995 . 7578250 . 10.1016/0167-4781(95)00159-e.
2. Web site: Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1.
3. Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S . PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1) . Mol. Endocrinol. . 14 . 7 . 986–98 . July 2000 . 10.1210/mend.14.7.0480 . 10894149 . free .
4. Zhou D, Chen S . PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif . Nucleic Acids Res. . 29 . 19 . 3939–48 . October 2001 . 11574675 . 60244 . 10.1093/nar/29.19.3939 .