PMP2 explained

Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene.^{[1] [2] [3]} Myelin protein P2 is a constituent of peripheral nervous system (PNS) myelin, also present in small amounts in central nervous system (CNS) myelin. As a structural protein, P2 is thought to stabilize the myelin membranes, and may play a role in lipid transport in Schwann cells. Structurally, P2 belongs to the family of cytoplasmicfatty acid-binding proteins (FABPs).

Further reading

• Narayanan V, Barbosa E, Reed R, Tennekoon G . Characterization of a cloned cDNA encoding rabbit myelin P2 protein . . 263 . 17 . 8332–7 . 1988 . 10.1016/S0021-9258(18)68481-9 . 2453513 . free .
• Jones TA, Bergfors T, Sedzik J, Unge T . The three-dimensional structure of P2 myelin protein . . 7 . 6 . 1597–604 . 1988 . 2458918 . 10.1002/j.1460-2075.1988.tb02985.x. 457142 .
• Ishaque A, Hofmann T, Eylar EH . The complete amino acid sequence of the rabbit P2 protein . . 257 . 2 . 592–5 . 1982 . 10.1016/S0021-9258(19)68231-1 . 6172423 . free .
• Suzuki M, Kitamura K, Sakamoto Y, Uyemura K . The complete amino acid sequence of human P2 protein . . 39 . 6 . 1759–62 . 1983 . 6183401 . 10.1111/j.1471-4159.1982.tb08017.x . 43779591 .
• Trapp BD, Dubois-Dalcq M, Quarles RH . Ultrastructural localization of P2 protein in actively myelinating rat Schwann cells . . 43 . 4 . 944–8 . 1984 . 6206203 . 10.1111/j.1471-4159.1984.tb12828.x . 37059056 .
• Narayanan V, Ripepi B, Jabs EW, etal . Partial structure and mapping of the human myelin P2 protein gene . . 63 . 6 . 2010–3 . 1994 . 7525873 . 10.1046/j.1471-4159.1994.63062010.x . 2027.42/65484 . 17388921 . free .
• Besançon R, Latour P, Lara K, etal . Exonic SNPs at positions 220 (A/G) and 445 (C/T) of the peripheral myelin protein 2 (PMP2) . . 17 . 3 . 237 . 2001 . 11241848 . 10.1002/humu.11 . 33419662 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Fortna A, Kim Y, MacLaren E, etal . Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution . . 2 . 7 . E207 . 2006 . 15252450 . 10.1371/journal.pbio.0020207 . 449870 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Hayasaka K, Nanao K, Tahara M, Sato W, Takada G, Miura M, Uyemura K . Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin . . 181 . 1 . 204–7 . Jan 1992 . 1720307 . 10.1016/S0006-291X(05)81402-0 .
2. Hayasaka K, Himoro M, Takada G, Takahashi E, Minoshima S, Shimizu N . Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2) . . 18 . 2 . 244–8 . Feb 1994 . 8288226 . 10.1006/geno.1993.1462 .
3. Web site: Entrez Gene: PMP2 peripheral myelin protein 2.