PLXNB1 explained

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.^{[1] [2] [3]}

Function

Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.^[4] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.^[5]

Interactions

PLXNB1 has been shown to interact with ARHGEF12,^[6] Rnd1^[7] and ARHGEF11.^{[6] [7] [8] [9]}

References

• Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A and Keegan AD. "Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1". ImmunoHorizons, February 1, 2019, 3 (2) 71-87;

Further reading

• Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 4 . 5 . 307–13 . 1998 . 9455477 . 10.1093/dnares/4.5.307 . free .
• Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM . Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates . Cell . 99 . 1 . 71–80 . 1999 . 10520995 . 10.1016/S0092-8674(00)80063-X . 17386412 . free .
• Vikis HG, Li W, Guan KL . The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding . Genes Dev. . 16 . 7 . 836–45 . 2002 . 11937491 . 186329 . 10.1101/gad.966402 .
• Swiercz JM, Kuner R, Behrens J, Offermanns S . Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology . Neuron . 35 . 1 . 51–63 . 2002 . 12123608 . 10.1016/S0896-6273(02)00750-X . 18981429 . free .
• Perrot V, Vazquez-Prado J, Gutkind JS . Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF . J. Biol. Chem. . 277 . 45 . 43115–20 . 2003 . 12183458 . 10.1074/jbc.M206005200 . free .
• Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL . The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG . Proc. Natl. Acad. Sci. U.S.A. . 99 . 19 . 12085–90 . 2002 . 12196628 . 129402 . 10.1073/pnas.142433199 . 2002PNAS...9912085A . free .
• Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L, Comoglio PM . The semaphorin 4D receptor controls invasive growth by coupling with Met . Nat. Cell Biol. . 4 . 9 . 720–4 . 2002 . 12198496 . 10.1038/ncb843 . 130071 .
• Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S . Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors . Biochem. Biophys. Res. Commun. . 297 . 1 . 32–7 . 2002 . 12220504 . 10.1016/S0006-291X(02)02122-8 .
• Granziero L, Circosta P, Scielzo C, Frisaldi E, Stella S, Geuna M, Giordano S, Ghia P, Caligaris-Cappio F . CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes . Blood . 101 . 5 . 1962–9 . 2003 . 12406905 . 10.1182/blood-2002-05-1339 . free .
• Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L . Functional regulation of semaphorin receptors by proprotein convertases . J. Biol. Chem. . 278 . 12 . 10094–101 . 2003 . 12533544 . 10.1074/jbc.M210156200 . free.
• Usui H, Taniguchi M, Yokomizo T, Shimizu T . Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains . Biochem. Biophys. Res. Commun. . 300 . 4 . 927–31 . 2003 . 12559962 . 10.1016/S0006-291X(02)02966-2 .
• Oinuma I, Katoh H, Harada A, Negishi M . Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells . J. Biol. Chem. . 278 . 28 . 25671–7 . 2003 . 12730235 . 10.1074/jbc.M303047200 . free .
• Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S . Interplay between scatter factor receptors and B plexins controls invasive growth . Oncogene . 23 . 30 . 5131–7 . 2004 . 15184888 . 10.1038/sj.onc.1207650 . 24596233 .
• Swiercz JM, Kuner R, Offermanns S . Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2 . J. Cell Biol. . 165 . 6 . 869–80 . 2004 . 15210733 . 2172401 . 10.1083/jcb.200312094 .
• Oinuma I, Ishikawa Y, Katoh H, Negishi M . The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras . Science . 305 . 5685 . 862–5 . 2004 . 15297673 . 10.1126/science.1097545 . 2004Sci...305..862O . 39544623 .
• Conrotto P, Valdembri D, Corso S, Serini G, Tamagnone L, Comoglio PM, Bussolino F, Giordano S . Sema4D induces angiogenesis through Met recruitment by Plexin B1 . Blood . 105 . 11 . 4321–9 . 2005 . 15632204 . 10.1182/blood-2004-07-2885 . free .

Notes and References

1. Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM . A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor . Proc Natl Acad Sci U S A . 93 . 2 . 674–8 . Mar 1996 . 8570614 . 40111 . 10.1073/pnas.93.2.674 . 1996PNAS...93..674M . free .
2. Vikis HG, Li W, He Z, Guan KL . The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner . Proc Natl Acad Sci U S A . 97 . 23 . 12457–62 . Nov 2000 . 11035813 . 18785 . 10.1073/pnas.220421797 . 2000PNAS...9712457V . free .
3. Web site: Entrez Gene: PLXNB1 plexin B1.
4. Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG . B plexins activate Rho through PDZ-RhoGEF. . FEBS Letters . 529 . 2–3 . 168–72 . Oct 9, 2002 . 12372594 . 10.1016/s0014-5793(02)03323-9 . 26525009 . free .
5. Basile JR, Afkhami T, Gutkind JS . Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. . Molecular and Cellular Biology . 25 . 16 . 6889–98 . Aug 2005 . 16055703 . 1190270 . 10.1128/mcb.25.16.6889-6898.2005 .
6. Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S . Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors . Biochem. Biophys. Res. Commun. . 297 . 1 . 32–7 . Sep 2002 . 12220504 . 10.1016/S0006-291X(02)02122-8 .
7. Oinuma I, Katoh H, Harada A, Negishi M . Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells . J. Biol. Chem. . 278 . 28 . 25671–7 . Jul 2003 . 12730235 . 10.1074/jbc.M303047200 . free .
8. Perrot V, Vazquez-Prado J, Gutkind JS . Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF . J. Biol. Chem. . 277 . 45 . 43115–20 . Nov 2002 . 12183458 . 10.1074/jbc.M206005200 . free .
9. Swiercz JM, Kuner R, Behrens J, Offermanns S . Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology . Neuron . 35 . 1 . 51–63 . Jul 2002 . 12123608 . 10.1016/S0896-6273(02)00750-X . 18981429 . free .