Phospholipid scramblase 1 explained

Phospholipid scramblase 1 (PL scramblase 1) is an enzyme that in humans is encoded by the PLSCR1 gene.^{[1] [2]}

Interactions

PLSCR1 has been shown to interact with:

• CPSF6,
• Epidermal growth factor receptor,
• NEU4,^[3]
• SHC1,^{[4] [5]}
• SLPI,^[6] and
• TFG.^[3]

See also

• Scramblase

Further reading

• Bassé F, Stout JG, Sims PJ, Wiedmer T . Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid. . J. Biol. Chem. . 271 . 29 . 17205–10 . 1996 . 8663431 . 10.1074/jbc.271.29.17205 . free .
• Zhou Q, Sims PJ, Wiedmer T . Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids. . Biochemistry . 37 . 8 . 2356–60 . 1998 . 9485382 . 10.1021/bi972625o .
• Zhao J, Zhou Q, Wiedmer T, Sims PJ . Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids. . Biochemistry . 37 . 18 . 6361–6 . 1998 . 9572851 . 10.1021/bi980218m .
• Kasukabe T, Kobayashi H, Kaneko Y, Okabe-Kado J, Honma Y . Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene . Biochem. Biophys. Res. Commun. . 249 . 2 . 449–55 . 1998 . 9712717 . 10.1006/bbrc.1998.9190 .
• Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ . Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha . Blood . 95 . 8 . 2593–9 . 2000 . 10753839 . 10.1182/blood.V95.8.2593.
• Frasch SC, Henson PM, Kailey JM, Richter DA, Janes MS, Fadok VA, Bratton DL . Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta . J. Biol. Chem. . 275 . 30 . 23065–73 . 2000 . 10770950 . 10.1074/jbc.M003116200 . free .
• Tseng CC, Tseng CP . Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement . FEBS Lett. . 475 . 3 . 232–6 . 2000 . 10869562 . 10.1016/S0014-5793(00)01700-2 . 35688498 .
• Wiedmer T, Zhou Q, Kwoh DY, Sims PJ . Identification of three new members of the phospholipid scramblase gene family . Biochim. Biophys. Acta . 1467 . 1 . 244–53 . 2000 . 10930526 . 10.1016/S0005-2736(00)00236-4 . free .
• Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ . c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1 . J. Biol. Chem. . 276 . 31 . 28984–90 . 2001 . 11390389 . 10.1074/jbc.M102505200 . free .
• Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ . Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1 . Cancer Res. . 62 . 2 . 397–402 . 2002 . 11809687 .
• Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ . Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor . Biochemistry . 41 . 20 . 6338–45 . 2002 . 12009895 . 10.1021/bi025610l .
• Zhou Q, Zhao J, Wiedmer T, Sims PJ . Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1 . Blood . 99 . 11 . 4030–8 . 2002 . 12010804 . 10.1182/blood-2001-12-0271 . free .
• Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS . Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase . J. Biol. Chem. . 277 . 31 . 28051–7 . 2002 . 12023963 . 10.1074/jbc.M202665200 . free .
• Nakamaki T, Okabe-Kado J, Yamamoto-Yamaguchi Y, ((Hino Ki)), Tomoyasu S, Honma Y, Kasukabe T . Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytes . Exp. Hematol. . 30 . 5 . 421–9 . 2002 . 12031648 . 10.1016/S0301-472X(02)00779-8 . free .
• Wiedmer T, Zhao J, Nanjundan M, Sims PJ . Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane . Biochemistry . 42 . 5 . 1227–33 . 2003 . 12564925 . 10.1021/bi026679w .
• Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y . Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)) . J. Biol. Chem. . 278 . 17 . 15239–45 . 2003 . 12586838 . 10.1074/jbc.M208611200 . free.
• Rami A, Sims J, Botez G, Winckler J . Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia . Neurochem. Int. . 43 . 1 . 79–87 . 2003 . 12605885 . 10.1016/S0197-0186(02)00194-8 . 44845123 .
• Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T . Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor . J. Biol. Chem. . 278 . 39 . 37413–8 . 2003 . 12871937 . 10.1074/jbc.M306182200 . free .

Notes and References

1. Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ . Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids . J Biol Chem . 272 . 29 . 18240–4 . August 1997 . 9218461 . 10.1074/jbc.272.29.18240 . free .
2. Web site: Entrez Gene: PLSCR1 phospholipid scramblase 1.
3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
4. Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ . Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor . Biochemistry . 41 . 20 . 6338–45 . May 2002 . 12009895 . 10.1021/bi025610l.
5. Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T . Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor . J. Biol. Chem. . 278 . 39 . 37413–8 . September 2003 . 12871937 . 10.1074/jbc.M306182200 . free .
6. Tseng CC, Tseng CP . Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement . FEBS Lett. . 475 . 3 . 232–6 . June 2000 . 10869562 . 10.1016/s0014-5793(00)01700-2. 35688498 .