PLRG1 explained

Pleiotropic regulator 1 is a protein that in humans is encoded by the PLRG1 gene.^[1]

Interactions

PLRG1 has been shown to interact with CDC5L.^{[2] [3] [4] [5]}

Further reading

• Németh K . Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis . Genes Dev. . 12 . 19 . 3059–73 . 1998 . 9765207 . 10.1101/gad.12.19.3059 . 317193 . vanc. Salchert K . Putnoky P . 3 . Bhalerao . R. . Koncz-Kalman . Z. . Stankovic-Stangeland . B. . Bako . L. . Mathur . J. . Okresz . L. .
• Ajuh P . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . EMBO J. . 19 . 23 . 6569–81 . 2001 . 11101529 . 10.1093/emboj/19.23.6569 . 305846 . vanc. Kuster B . Panov K . 3 . Zomerdijk . JC . Mann . M . Lamond . AI .
• Ajuh P, Sleeman J, Chusainow J, Lamond AI . A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing . J. Biol. Chem. . 276 . 45 . 42370–81 . 2001 . 11544257 . 10.1074/jbc.M105453200 . free .
• Rappsilber J, Ryder U, Lamond AI, Mann M . Large-scale proteomic analysis of the human spliceosome . Genome Res. . 12 . 8 . 1231–45 . 2002 . 12176931 . 10.1101/gr.473902 . 186633 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Ajuh P, Lamond AI . Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1 . Nucleic Acids Res. . 31 . 21 . 6104–16 . 2003 . 14576297 . 10.1093/nar/gkg817 . 275459 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A. 4344740 .
• Ewing RM . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . vanc. Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .

Notes and References

1. Web site: Entrez Gene: PLRG1 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis).
2. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . 2007. Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 17353931 . 10.1038/msb4100134 . 1847948 .
3. Ajuh P, Lamond AI . November 2003 . Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1 . Nucleic Acids Res. . 31 . 21 . 6104–16 . 14576297 . 10.1093/nar/gkg817 . 275459 .
4. Ajuh P, Sleeman J, Chusainow J, Lamond AI . November 2001 . A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing . J. Biol. Chem. . 276 . 45 . 42370–81 . 0021-9258. 11544257 . 10.1074/jbc.M105453200 . free .
5. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . EMBO J. . 19 . 23 . 6569–81 . 2000 . 11101529 . 305846 . 10.1093/emboj/19.23.6569 .