PLK2 explained

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.^[1]

Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division. [supplied by OMIM]^[1]

Further reading

• Kauselmann G, Weiler M, Wulff P, etal . The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. . EMBO J. . 18 . 20 . 5528–39 . 1999 . 10523297 . 10.1093/emboj/18.20.5528 . 1171621 .
• Ouyang B, Li W, Pan H, etal . The physical association and phosphorylation of Cdc25C protein phosphatase by Prk. . Oncogene . 18 . 44 . 6029–36 . 1999 . 10557092 . 10.1038/sj.onc.1202983 . free .
• Holtrich U, Wolf G, Yuan J, etal . Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. . Oncogene . 19 . 42 . 4832–9 . 2000 . 11039900 . 10.1038/sj.onc.1203845 . free .
• Liby K, Wu H, Ouyang B, etal . Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase. . DNA Seq. . 11 . 6 . 527–33 . 2002 . 11696980 . 10.3109/10425170109041337 . 46552280 .
• Shimizu-Yoshida Y, Sugiyama K, Rogounovitch T, etal . Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells. . Biochem. Biophys. Res. Commun. . 289 . 2 . 491–8 . 2002 . 11716500 . 10.1006/bbrc.2001.5993 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ma S, Liu MA, Yuan YL, Erikson RL . The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB. . Mol. Cancer Res. . 1 . 5 . 376–84 . 2003 . 12651910 .
• Matsuda A, Suzuki Y, Honda G, etal . Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. . Oncogene . 22 . 21 . 3307–18 . 2003 . 12761501 . 10.1038/sj.onc.1206406 . free .
• Burns TF, Fei P, Scata KA, etal . Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. . Mol. Cell. Biol. . 23 . 16 . 5556–71 . 2003 . 12897130 . 10.1128/MCB.23.16.5556-5571.2003 . 166320 .
• Ma S, Charron J, Erikson RL . Role of Plk2 (Snk) in mouse development and cell proliferation. . Mol. Cell. Biol. . 23 . 19 . 6936–43 . 2003 . 12972611 . 10.1128/MCB.23.19.6936-6943.2003 . 193943 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Yogosawa S, Hatakeyama S, Nakayama KI, etal . Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. . J. Biol. Chem. . 280 . 50 . 41619–27 . 2006 . 16203730 . 10.1074/jbc.M508397200 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Park YY, Kim SH, Kim YJ, etal . Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRgamma). . Biochem. Biophys. Res. Commun. . 362 . 1 . 107–13 . 2007 . 17706602 . 10.1016/j.bbrc.2007.07.170 .
• Matthew EM, Yen TJ, Dicker DT, etal . Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells. . Cell Cycle . 6 . 20 . 2571–8 . 2007 . 17912033 . 10.4161/cc.6.20.5079 . free .

Notes and References

1. Web site: Entrez Gene: PLK2 polo-like kinase 2 (Drosophila).