PLEK2 explained

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene.^{[1] [2] [3]} The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.^[4]

Further reading

• Bach TL, Kerr WT, Wang Y, etal . PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization. . Blood . 109 . 3 . 1147–55 . 2007 . 17008542 . 10.1182/blood-2006-02-001339 . 1785144 .
• Inazu T, Kuroiwa A, Matsuda Y, Miyamoto K . Cloning, expression and chromosomal assignment of human pleckstrin 2. . Mol. Biol. Rep. . 32 . 1 . 35–40 . 2005 . 15865208 . 10.1007/s11033-004-4747-x . 8131790 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Inazu T, Yamada K, Miyamoto K . Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family. . Biochem. Biophys. Res. Commun. . 265 . 1 . 87–93 . 1999 . 10548495 . 10.1006/bbrc.1999.1461 .
• Hu MH, Bauman EM, Roll RL, etal . Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement. . J. Biol. Chem. . 274 . 31 . 21515–8 . 1999 . 10419454 . 10.1074/jbc.274.31.21515 . free .
• Hillier LD, Lennon G, Becker M, etal . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . free .

Notes and References

1. Lemmon. Mark A.. Mark A. Lemmon. Ferguson. Kathryn M.. Abrams. Charles S.. Pleckstrin homology domains and the cytoskeleton. FEBS Letters. 513. 1. 2002. 71–76. 11911883. 10.1016/S0014-5793(01)03243-4. free.
2. Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y . Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading . Biochem Biophys Res Commun . 361 . 2 . 270–5 . Aug 2007 . 17658464 . 10.1016/j.bbrc.2007.06.132 .
3. Web site: Entrez Gene: PLEK2 pleckstrin 2.
4. Web site: AceView: PLEK2 gene. AceView. National Library of Medicine. 24 April 2011.