PLCD4 explained

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 is an enzyme that in humans is encoded by the PLCD4 gene.^{[1] [2] [3]}

Further reading

• Cefai D, Debre P, Kaczorek M, etal . Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway . J. Clin. Invest. . 86 . 6 . 2117–24 . 1991 . 1979339 . 10.1172/JCI114950 . 329852 .
• Zauli G, Previati M, Caramelli E, etal . Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line . Eur. J. Immunol. . 25 . 9 . 2695–700 . 1995 . 7589147 . 10.1002/eji.1830250944 . 20562627 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Chen P, Mayne M, Power C, Nath A . The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases . J. Biol. Chem. . 272 . 36 . 22385–8 . 1997 . 9278385 . 10.1074/jbc.272.36.22385 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Mayne M, Bratanich AC, Chen P, etal . HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease . Neuroimmunomodulation . 5 . 3–4 . 184–92 . 1998 . 9730685 . 10.1159/000026336 . 19529677 .
• Haughey NJ, Holden CP, Nath A, Geiger JD . Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat . J. Neurochem. . 73 . 4 . 1363–74 . 1999 . 10501179 . 10.1046/j.1471-4159.1999.0731363.x . 25410140 .
• Mayne M, Holden CP, Nath A, Geiger JD . Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages . J. Immunol. . 164 . 12 . 6538–42 . 2000 . 10843712 . 10.4049/jimmunol.164.12.6538. free .
• Ananthanarayanan B, Das S, Rhee SG, etal . Membrane targeting of C2 domains of phospholipase C-delta isoforms . J. Biol. Chem. . 277 . 5 . 3568–75 . 2002 . 11706040 . 10.1074/jbc.M109705200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E . Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha . Virology . 303 . 1 . 174–80 . 2003 . 12482669 . 10.1006/viro.2002.1676 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Lee SB, Várnai P, Balla A, etal . The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme . J. Biol. Chem. . 279 . 23 . 24362–71 . 2004 . 15037625 . 10.1074/jbc.M312772200 . free .
• Leung DW, Tompkins C, Brewer J, etal . Phospholipase C δ-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells . Mol. Cancer . 3 . 15 . 2004 . 15140260 . 10.1186/1476-4598-3-15 . 420486 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Chae SW, Kim JM, Yun YP, etal . Identification and analysis of the promoter region of the human PLC-delta4 gene . Mol. Biol. Rep. . 34 . 2 . 69–77 . 2007 . 17394098 . 10.1007/s11033-006-9014-x . 24577383 .

Notes and References

1. Kim H, Suh PG, Ryu SH, Park SH . Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization . Cytogenet Cell Genet . 87 . 3–4 . 254–5 . Apr 2000 . 10702683 . 10.1159/000015437 . 40877378 .
2. Ghosh S, Pawelczyk T, Lowenstein JM . Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties . Protein Expr Purif . 9 . 2 . 262–78 . Jun 1997 . 9056492 . 10.1006/prep.1996.0682.
3. Web site: Entrez Gene: PLCD4 phospholipase C, delta 4.