PLCB3 explained

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.^{[1] [2]}

The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.^[3]

Further reading

• Carozzi AJ, Kriz RW, Webster C, Parker PJ . Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily . Eur. J. Biochem. . 210 . 2 . 521–9 . 1992 . 1333955 . 10.1111/j.1432-1033.1992.tb17450.x .
• Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G . Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway . J. Clin. Invest. . 86 . 6 . 2117–24 . 1990 . 1979339 . 329852 . 10.1172/JCI114950 .
• Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S . Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line . Eur. J. Immunol. . 25 . 9 . 2695–700 . 1995 . 7589147 . 10.1002/eji.1830250944 . 20562627 .
• Lagercrantz J, Carson E, Phelan C, Grimmond S, Rosén A, Daré E, Nordenskjöld M, Hayward NK, Larsson C, Weber G . Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3) . Genomics . 26 . 3 . 467–72 . 1995 . 7607669 . 10.1016/0888-7543(95)80164-H .
• Mazuruk K, Schoen TJ, Chader GJ, Rodriguez IR . Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene . Biochem. Biophys. Res. Commun. . 212 . 1 . 190–5 . 1995 . 7612006 . 10.1006/bbrc.1995.1955 .
• Sinke RJ, Geurts van Kessel AG . Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13 . Genomics . 25 . 2 . 568–9 . 1995 . 7789993 . 10.1016/0888-7543(95)80060-Y .
• Chen P, Mayne M, Power C, Nath A . The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases . J. Biol. Chem. . 272 . 36 . 22385–8 . 1997 . 9278385 . 10.1074/jbc.272.36.22385 . free .
• Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP . GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain . J. Biol. Chem. . 273 . 28 . 17749–55 . 1998 . 9651375 . 10.1074/jbc.273.28.17749 . free .
• Wang S, Zhou Y, Lukinius A, Oberg K, Skogseid B, Gobl A . Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3 . Biochim. Biophys. Acta . 1393 . 1 . 173–8 . 1998 . 9714794 . 10.1016/s0005-2760(98)00074-5 .
• Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C . HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease . Neuroimmunomodulation . 5 . 3–4 . 184–92 . 1998 . 9730685 . 10.1159/000026336 . 19529677 .
• Haughey NJ, Holden CP, Nath A, Geiger JD . Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat . J. Neurochem. . 73 . 4 . 1363–74 . 1999 . 10501179 . 10.1046/j.1471-4159.1999.0731363.x . 25410140 .
• Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG . Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2 . J. Biol. Chem. . 275 . 22 . 16632–7 . 2000 . 10748023 . 10.1074/jbc.M001410200 . free .
• Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK . Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta . J. Biol. Chem. . 275 . 24 . 18418–23 . 2000 . 10748198 . 10.1074/jbc.M910211199 . free .
• Mayne M, Holden CP, Nath A, Geiger JD . Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages . J. Immunol. . 164 . 12 . 6538–42 . 2000 . 10843712 . 10.4049/jimmunol.164.12.6538 . free .
• Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC . Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1) . Biochim. Biophys. Acta . 1517 . 1 . 63–72 . 2000 . 11118617 . 10.1016/S0167-4781(00)00260-8 .
• Stålberg P, Lopez-Egido JR, Wang S, Gobl A, Oberg K, Skogseid B . Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene . Biochem. Biophys. Res. Commun. . 281 . 1 . 227–31 . 2001 . 11178984 . 10.1006/bbrc.2001.4329 .
• Xia C, Bao Z, Yue C, Sanborn BM, Liu M . Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases . J. Biol. Chem. . 276 . 23 . 19770–7 . 2001 . 11278298 . 10.1074/jbc.M006266200 . free .
• Yue C, Sanborn BM . KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser . Mol. Cell. Endocrinol. . 175 . 1–2 . 149–56 . 2001 . 11325525 . 10.1016/S0303-7207(01)00383-5 . 338776 .
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E . Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha . Virology . 303 . 1 . 174–80 . 2002 . 12482669 . 10.1006/viro.2002.1676 . free .

Notes and References

1. Weber G, Friedman E, Grimmond S, Hayward NK, Phelan C, Skogseid B, Gobl A, Zedenius J, Sandelin K, Teh BT . The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours . Hum. Mol. Genet. . 3 . 10 . 1775–81 . March 1995 . 7849701 . 10.1093/hmg/3.10.1775 .
2. Web site: Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific).
3. Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG . Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2 . J. Biol. Chem. . 275 . 22 . 16632–7 . June 2000 . 10748023 . 10.1074/jbc.M001410200 . free .