PLAGL2 explained

Zinc finger protein PLAGL2 is a protein that in humans is encoded by the PLAGL2 gene.^{[1] [2] [3]}

Zinc finger protein PLAGL2 is a zinc finger protein that recognizes DNA and/or RNA.

The gene has seen in gliomas to suppress cellular differentiation and thus encourage cells to become more stem cell like. Such plasticity is seen in glioma cells, together with the ignorance to differentiation factors.^[4]

Further reading

• Guo Y, Yang MC, Weissler JC, Yang YS . PLAGL2 Translocation and SP-C Promoter Activity – A Cellular Response of Lung Cells to Hypoxia . Biochem. Biophys. Res. Commun. . 360 . 3 . 659–65 . 2007 . 17618602 . 10.1016/j.bbrc.2007.06.106 . 2084061 .
• Ammons MC, Siemsen DW, Nelson-Overton LK, etal . Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 promoter regulates p67(phox) expression and NADPH oxidase activity . J. Biol. Chem. . 282 . 24 . 17941–52 . 2007 . 17462995 . 10.1074/jbc.M610618200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Yang MC, Weissler JC, Terada LS, etal . Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter . Am. J. Respir. Cell Mol. Biol. . 32 . 1 . 35–43 . 2005 . 15361364 . 10.1165/rcmb.2003-0422OC . 10.1.1.325.6715 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Furukawa T, Adachi Y, Fujisawa J, etal . Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines . Oncogene . 20 . 34 . 4718–27 . 2001 . 11498794 . 10.1038/sj.onc.1204647 . free .
• Kas K, Voz ML, Hensen K, etal . Transcriptional activation capacity of the novel PLAG family of zinc finger proteins . J. Biol. Chem. . 273 . 36 . 23026–32 . 1998 . 9722527 . 10.1074/jbc.273.36.23026 . free .
• Nagase T, Seki N, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 3 . 1 . 17–24 . 1996 . 8724849 . 10.1093/dnares/3.1.17 . free .

Notes and References

1. Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH . Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11 . Blood . 105 . 7 . 2900–7 . Mar 2005 . 15585652 . 10.1182/blood-2004-09-3630 . free .
2. Zheng G, Ning J, Yang YC . PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53 . Biochem Biophys Res Commun . 364 . 2 . 344–50 . Oct 2007 . 17950244 . 2708094 . 10.1016/j.bbrc.2007.10.003 .
3. Web site: Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2.
4. Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA . PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma . Cancer Cell . 17 . 5 . 497–509 . May 2010 . 20478531 . 2900858 . 10.1016/j.ccr.2010.03.020 .