PLAGL1 explained

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.^{[1] [2] [3]}

Function

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.

Interactions

PLAGL1 has been shown to interact with P53.^[4]

Further reading

• Vernon M . Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications . J Deaf Stud Deaf Educ . 10 . 3 . 225–31 . 2005 . 15888725 . 10.1093/deafed/eni024 . free .
• Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC . Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors . Oncogene . 14 . 16 . 1973–9 . 1997 . 9150364 . 10.1038/sj.onc.1201034 . 24314159 .
• Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC . Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells . Cancer Res. . 57 . 10 . 2029–34 . 1997 . 9158001 .
• Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L . Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain . EMBO J. . 16 . 10 . 2814–25 . 1997 . 9184226 . 1169890 . 10.1093/emboj/16.10.2814 .
• Abdollahi A, Bao R, Hamilton TC . LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein . Oncogene . 18 . 47 . 6477–87 . 1999 . 10597250 . 10.1038/sj.onc.1203067 . 25450943 .
• Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron DT, Hayashizaki Y . The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes . Hum. Mol. Genet. . 9 . 3 . 453–60 . 2000 . 10655556 . 10.1093/hmg/9.3.453 . free .
• Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L . Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities . Oncogene . 20 . 10 . 1246–53 . 2001 . 11313869 . 10.1038/sj.onc.1204237 . free .
• Huang SM, Schönthal AH, Stallcup MR . Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1 . Oncogene . 20 . 17 . 2134–43 . 2001 . 11360197 . 10.1038/sj.onc.1204298 . 21331603 .
• Mackay DJ, Coupe AM, Shield JP, Storr JN, Temple IK, Robinson DO . Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus . Hum. Genet. . 110 . 2 . 139–44 . 2002 . 11935319 . 10.1007/s00439-001-0671-5 . 22321580 .
• Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC . LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer . J. Biol. Chem. . 278 . 8 . 6041–9 . 2003 . 12473647 . 10.1074/jbc.M210361200 . free .
• Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D . Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding . Mol. Cell. Biol. . 23 . 3 . 988–1003 . 2003 . 12529403 . 140694 . 10.1128/MCB.23.3.988-1003.2003 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R, Rutter GA, Kelsey G . Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM . J. Clin. Invest. . 114 . 3 . 339–48 . 2004 . 15286800 . 484972 . 10.1172/JCI19876 .
• Cvetkovic D, Pisarcik D, Lee C, Hamilton TC, Abdollahi A . Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer . Gynecol. Oncol. . 95 . 3 . 449–55 . 2004 . 15581945 . 10.1016/j.ygyno.2004.08.051 .
• Mitchell J, Punthakee Z, Lo B, Bernard C, Chong K, Newman C, Cartier L, Desilets V, Cutz E, Hansen IL, Riley P, Polychronakos C . Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome . Diabetologia . 47 . 12 . 2160–7 . 2004 . 15592663 . 10.1007/s00125-004-1576-3 . free .

Notes and References

1. Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ . Transcriptional activation capacity of the novel PLAG family of zinc finger proteins . J. Biol. Chem. . 273 . 36 . 23026–32 . Oct 1998 . 9722527 . 10.1074/jbc.273.36.23026 . free .
2. Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L . hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer . Proc. Natl. Acad. Sci. U.S.A. . 95 . 15 . 8835–40 . Aug 1998 . 9671765 . 21163 . 10.1073/pnas.95.15.8835 . 1998PNAS...95.8835V . free .
3. Web site: Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1.
4. Huang SM, Schönthal AH, Stallcup MR . Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1 . Oncogene . 20 . 17 . 2134–43 . Apr 2001 . 11360197 . 10.1038/sj.onc.1204298 . 21331603 .