PLA2G4C explained

Cytosolic phospholipase A₂ gamma is an enzyme that in humans is encoded by the PLA2G4C gene.^{[1] [2]}

See also

• Phospholipase A₂

Further reading

• Schröder HC . Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death . Neurotoxicology . 19 . 4–5 . 683–8 . 1998 . 9745929 . Perovic S . Kavsan V . Ushijima . H . Müller . WE .
• Wu T . P11, a unique member of the S100 family of calcium-binding proteins, interacts with and inhibits the activity of the 85-kDa cytosolic phospholipase A2 . J. Biol. Chem. . 272 . 27 . 17145–53 . 1997 . 9202034 . 10.1074/jbc.272.27.17145 . Angus CW . Yao XL . Logun . C . Shelhamer . JH . free.
• Mavoungou E . HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. . 16 . 1 . 1–9 . 1997 . 9377118 . 10.1097/00042560-199709010-00001. Georges-Courbot MC . Poaty-Mavoungou V . Nguyen . HT . Yaba . P . Delicat . A . Georges . AJ . Russo-Marie . F . free .
• Pickard RT, Strifler BA, Kramer RM, Sharp JD . Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2 . J. Biol. Chem. . 274 . 13 . 8823–31 . 1999 . 10085124 . 10.1074/jbc.274.13.8823 . free .
• Smith JS . A transcript map of the chromosome 19q-arm glioma tumor suppressor region . Genomics . 64 . 1 . 44–50 . 2000 . 10708517 . 10.1006/geno.1999.6101 . Tachibana I . Pohl U . Lee . HK . Thanarajasingam . U . Portier . BP . Ueki . K . Ramaswamy . S . Billings . SJ .
• Hartmann C . Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas . Brain Pathol. . 12 . 2 . 178–82 . 2002 . 11958371 . 10.1111/j.1750-3639.2002.tb00432.x . Johnk L . Sasaki H . Jenkins . Robert B. . Louis . David N. . 2579203 . 8095768.
• Stewart A, Ghosh M, Spencer DM, Leslie CC . Enzymatic properties of human cytosolic phospholipase A(2)gamma . J. Biol. Chem. . 277 . 33 . 29526–36 . 2002 . 12039969 . 10.1074/jbc.M204856200 . free .
• Lindbom J, Ljungman AG, Lindahl M, Tagesson C . Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma . J. Interferon Cytokine Res. . 22 . 9 . 947–55 . 2003 . 12396716 . 10.1089/10799900260286650 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Asai K . Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress . J. Biol. Chem. . 278 . 10 . 8809–14 . 2003 . 12502717 . 10.1074/jbc.M212117200 . Hirabayashi T . Houjou T . Uozumi . N . Taguchi . R . Shimizu . T . free.
• Jenkins CM . Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis . Biochemistry . 42 . 40 . 11798–807 . 2004 . 14529291 . 10.1021/bi034611q . Han X . Yang J . Mancuso . David J. . Sims . Harold F. . Muslin . Anthony J. . Gross . Richard W. .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Dong M . Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis . Clin. Cancer Res. . 11 . 6 . 2265–71 . 2005 . 15788676 . 10.1158/1078-0432.CCR-04-1079 . Johnson M . Rezaie A . Ilsley . JN . Nakanishi . M . Sanders . MM . Forouhar . F . Levine . J . Montrose . DC . free .
• Yan W . The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling . J. Biol. Chem. . 280 . 29 . 26669–79 . 2005 . 15908428 . 10.1074/jbc.M502358200 . Jenkins CM . Han X . Mancuso . DJ . Sims . HF . Yang . K . Gross . RW . free .
• Yamashita A . Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma) . J. Biochem. . 137 . 5 . 557–67 . 2005 . 15944408 . 10.1093/jb/mvi067 . Kamata R . Kawagishi N . Nakanishi . H . Suzuki . H . Sugiura . T . Waku . K .
• Zhao X . Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells . J. Biol. Chem. . 281 . 39 . 29357–68 . 2006 . 16882668 . 10.1074/jbc.M513105200 . Wang D . Zhao Z . Xiao . Y . Sengupta . S . Xiao . Y . Zhang . R . Lauber . K . Wesselborg . S . free .

Notes and References

1. Underwood KW, Song C, Kriz RW, Chang XJ, Knopf JL, Lin LL . A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2 . J Biol Chem . 273 . 34 . 21926–32 . Sep 1998 . 9705332 . 10.1074/jbc.273.34.21926 . free .
2. Web site: Entrez Gene: PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent).