PLA2G2A explained

Phospholipase A2, membrane associated is an enzyme that in humans is encoded by the PLA2G2A gene.^{[1] [2]}

See also

• Phospholipase A2

Further reading

• Book: Kramer RM, Johansen B, Hession C, Pepinsky RB . Structure and Properties of a Secretable Phospholipase A2 from Human Platelets . Phospholipase A2 . Advances in Experimental Medicine and Biology . 275 . 35–53 . 1990 . 2239446 . 10.1007/978-1-4684-5805-3_3. 978-1-4684-5807-7 .
• Schröder HC . Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death . Neurotoxicology . 19 . 4–5 . 683–8 . 1998 . 9745929 . Perovic S . Kavsan V . Ushijima . H . Müller . WE .
• Law MH, Cotton RG, Berger GE . The role of phospholipases A2 in schizophrenia . Mol. Psychiatry . 11 . 6 . 547–56 . 2006 . 16585943 . 10.1038/sj.mp.4001819 . 13248313 .
• Carlquist JF, Muhlestein JB, Anderson JL . Lipoprotein-associated phospholipase A2: a new biomarker for cardiovascular risk assessment and potential therapeutic target . Expert Rev. Mol. Diagn. . 7 . 5 . 511–7 . 2007 . 17892360 . 10.1586/14737159.7.5.511 . 23148887 .
• Scott DL . Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate . Science . 254 . 5034 . 1007–10 . 1991 . 1948070 . 10.1126/science.1948070 . White SP . Browning JL . Rosa . J. . Gelb . M. . Sigler . P. . 1991Sci...254.1007S .
• Pruzanski W . Enzymatic activity and distribution of phospholipase A2 in human cartilage . Life Sci. . 48 . 25 . 2457–62 . 1991 . 2046470 . 10.1016/0024-3205(91)90381-K . Bogoch E . Stefanski E . Wloch . M. . Vadas . P. .
• Wery JP . Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution . Nature . 352 . 6330 . 79–82 . 1991 . 2062381 . 10.1038/352079a0 . Schevitz RW . Clawson DK . Bobbitt . J. L . Dow . E. R . Gamboa . G . Goodson Jr . T . Hermann . R. B . Kramer . R. M . 1991Natur.352...79W . 4238043 .
• Seilhamer JJ . Novel gene exon homologous to pancreatic phospholipase A2: sequence and chromosomal mapping of both human genes . J. Cell. Biochem. . 39 . 3 . 327–37 . 1989 . 2708461 . 10.1002/jcb.240390312 . Randall TL . Johnson LK . Heinzmann . C. . Klisak . I. . Sparkes . R. S. . Lusis . A. J. . 40949411 .
• Kanda A . The primary structure of a membrane-associated phospholipase A2 from human spleen . Biochem. Biophys. Res. Commun. . 163 . 1 . 42–8 . 1989 . 2775276 . 10.1016/0006-291X(89)92096-2 . Ono T . Yoshida N . Tojo . Hiromasa . Okamoto . Mitsuhiro .
• Seilhamer JJ . Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid . J. Biol. Chem. . 264 . 10 . 5335–8 . 1989 . 2925608 . Pruzanski W . Vadas P . Plant . S . Miller . JA . Kloss . J . Johnson . LK . 10.1016/S0021-9258(18)83549-9 . free .
• Kramer RM . Structure and properties of a human non-pancreatic phospholipase A2 . J. Biol. Chem. . 264 . 10 . 5768–75 . 1989 . 2925633 . Hession C . Johansen B . Hayes . G . McGray . P . Chow . EP . Tizard . R . Pepinsky . RB . 10.1016/S0021-9258(18)83616-X . free .
• Lai CY, Wada K . Phospholipase A2 from human synovial fluid: purification and structural homology to the placental enzyme . Biochem. Biophys. Res. Commun. . 157 . 2 . 488–93 . 1989 . 3202859 . 10.1016/S0006-291X(88)80275-4 .
• Hara S . Amino acid composition and NH2-terminal amino acid sequence of human phospholipase A2 purified from rheumatoid synovial fluid . J. Biochem. . 104 . 3 . 326–8 . 1989 . 3240982 . Kudo I . Matsuta K . Miyamoto . T . Inoue . K . 10.1093/oxfordjournals.jbchem.a122467 .
• Schevitz RW . Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2 . Nat. Struct. Biol. . 2 . 6 . 458–65 . 1995 . 7664108 . 10.1038/nsb0695-458 . Bach NJ . Carlson DG . Chirgadze . N.Y. . Clawson . D.K. . Dillard . R.D. . Draheim . S.E. . Hartley . L.W. . Jones . N.D. . 7097651 .
• Ancian P, Lambeau G, Mattéi MG, Lazdunski M . The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization . J. Biol. Chem. . 270 . 15 . 8963–70 . 1995 . 7721806 . 10.1074/jbc.270.15.8963. free .
• MacPhee M . The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia . Cell . 81 . 6 . 957–66 . 1995 . 7781071 . 10.1016/0092-8674(95)90015-2 . Chepenik KP . Liddell RA . Nelson . Kelly K . Siracusa . Linda D . Buchberg . Arthur M . 16493676 . free.
• Minami T . Purification and characterization of a phospholipase A2 from human ileal mucosa . Biochim. Biophys. Acta . 1170 . 2 . 125–30 . 1993 . 8399335 . 10.1016/0005-2760(93)90061-d. Tojo H . Shinomura Y . Matsuzawa . Y . Okamoto . M .
• Sartipy P . Binding of human phospholipase A2 type II to proteoglycans. Differential effect of glycosaminoglycans on enzyme activity . J. Biol. Chem. . 271 . 42 . 26307–14 . 1996 . 8824283 . 10.1074/jbc.271.42.26307 . Johansen B . Camejo G . Rosengren . B . Bondjers . G . Hurt-Camejo . E . free .

Notes and References

1. Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ . Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human . Genomics . 32 . 3 . 328–33 . Feb 1997 . 8838795 . 10.1006/geno.1996.0126 .
2. Web site: Entrez Gene: PLA2G2A Phospholipase A2, group IIA (platelets, synovial fluid).