PLA2G12A explained

Group XIIA secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G12A gene.^{[1] [2]}

Further reading

• Schröder HC, Perovic S, Kavsan V, etal . Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. . Neurotoxicology . 19 . 4–5 . 683–8 . 1998 . 9745929 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rouault M, Bollinger JG, Lazdunski M, etal . Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity . Biochemistry . 42 . 39 . 11494–503 . 2003 . 14516201 . 10.1021/bi0349930 .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Murakami M, Masuda S, Shimbara S, etal . Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII) . J. Biol. Chem. . 278 . 12 . 10657–67 . 2003 . 12522102 . 10.1074/jbc.M211325200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ho IC, Arm JP, Bingham CO, etal . A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells . J. Biol. Chem. . 276 . 21 . 18321–6 . 2001 . 11278438 . 10.1074/jbc.M008837200 . free .
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, etal . HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. . 16 . 1 . 1–9 . 1997 . 9377118 . 10.1097/00042560-199709010-00001. free .

Notes and References

1. Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G . Cloning and recombinant expression of a structurally novel human secreted phospholipase A2 . J Biol Chem . 275 . 51 . 39823–6 . Jan 2001 . 11031251 . 3422575. 10.1074/jbc.C000671200 . free .
2. Web site: Entrez Gene: PLA2G12A phospholipase A2, group XIIA.