PKIG explained

cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene.^{[1] [2]}

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported.

Further reading

• Collins SP, Uhler MD . Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase . J. Biol. Chem. . 272 . 29 . 18169–78 . 1997 . 9218452 . 10.1074/jbc.272.29.18169 . free .
• Fossey SC, Mychaleckyj JC, Pendleton JK, etal . A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 . Genomics . 76 . 1–3 . 45–57 . 2001 . 11549316 . 10.1006/geno.2001.6584 .
• Lum H, Hao Z, Gayle D, etal . Vascular endothelial cells express isoforms of protein kinase A inhibitor . Am. J. Physiol., Cell Physiol. . 282 . 1 . C59–66 . 2002 . 11742798 . 10.1152/ajpcell.00256.2001 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Yu J, Yu L, Chen Z, etal . Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors . Brain Res. Mol. Brain Res. . 99 . 2 . 145–9 . 2002 . 11978406 . 10.1016/S0169-328X(02)00104-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Zhao L, Yang S, Zhou GQ, etal . Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation . Int. J. Biochem. Cell Biol. . 38 . 12 . 2064–73 . 2006 . 16870489 . 10.1016/j.biocel.2006.05.015 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S . Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA . Biochem J . 349 . Pt 2 . 403–7 . Jan 2001 . 10880337 . 1221161 . 10.1042/0264-6021:3490403 .
2. Web site: Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma.