PKIB explained

cAMP-dependent protein kinase inhibitor beta is a protein that in humans is encoded by the PKIB gene.^{[1] [2]}

The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. Studies of a similar protein in rat suggest that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor. At least three alternatively spliced transcript variants encoding the same protein have been reported.

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . free .
• Giangrande PH, Hallstrom TC, Tunyaplin C, etal . Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor . Mol. Cell. Biol. . 23 . 11 . 3707–20 . 2003 . 12748276 . 10.1128/MCB.23.11.3707-3720.2003 . 155231 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Qi ZY, Li Y, Ying K, etal . Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes . J. Neurooncol. . 56 . 3 . 197–208 . 2002 . 12061725 . 10.1023/A:1015079705841 . 23878825 .
• Yu J, Yu L, Chen Z, etal . Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors . Brain Res. Mol. Brain Res. . 99 . 2 . 145–9 . 2002 . 11978406 . 10.1016/S0169-328X(02)00104-3 .
• Scarpetta MA, Uhler MD . Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse . J. Biol. Chem. . 268 . 15 . 10927–31 . 1993 . 10.1016/S0021-9258(18)82074-9 . 7684369 . free .
• Van Patten SM, Ng DC, Th'ng JP, etal . Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase . Proc. Natl. Acad. Sci. U.S.A. . 88 . 12 . 5383–7 . 1991 . 2052616 . 10.1073/pnas.88.12.5383 . 51877 . free . 1991PNAS...88.5383V .

Notes and References

1. Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S . Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA . Biochem J . 349 . Pt 2 . 403–7 . Jan 2001 . 10880337 . 1221161 . 10.1042/0264-6021:3490403 .
2. Web site: Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta.