PKIA explained

cAMP-dependent protein kinase inhibitor alpha is a protein that in humans is encoded by the PKIA gene.^{[1] [2]}

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.

Further reading

• Olsen SR, Uhler MD . Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase . J. Biol. Chem. . 266 . 17 . 11158–11162 . 1991 . 10.1016/S0021-9258(18)99142-8 . 1710219 . free .
• Knighton DR, Zheng JH, Ten Eyck LF, etal . Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase . Science . 253 . 5018 . 414–420 . 1991 . 1862343 . 10.1126/science.1862343 . 1991Sci...253..414K .
• Van Patten SM, Heisermann GJ, Cheng HC, Walsh DA . Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase . J. Biol. Chem. . 262 . 7 . 3398–3403 . 1987 . 10.1016/S0021-9258(18)61516-9 . 2434500 . free .
• Scott JD, Fischer EH, Demaille JG, Krebs EG . Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase . Proc. Natl. Acad. Sci. U.S.A. . 82 . 13 . 4379–4383 . 1985 . 2989819 . 10.1073/pnas.82.13.4379 . 390417 . 1985PNAS...82.4379S . free .
• Scott JD, Glaccum MB, Fischer EH, Krebs EG . Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase . Proc. Natl. Acad. Sci. U.S.A. . 83 . 6 . 1613–1616 . 1986 . 3456605 . 10.1073/pnas.83.6.1613 . 323133 . 1986PNAS...83.1613S . free .
• Wen W, Taylor SS, Meinkoth JL . The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated . J. Biol. Chem. . 270 . 5 . 2041–2046 . 1995 . 7836431 . 10.1074/jbc.270.5.2041 . free .
• Baude EJ, Dignam SS, Olsen SR, etal . Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor . J. Biol. Chem. . 269 . 3 . 2316–2323 . 1994 . 10.1016/S0021-9258(17)42170-3 . 7905001 . free .
• Baude EJ, Dignam SS, Reimann EM, Uhler MD . Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors . J. Biol. Chem. . 269 . 27 . 18128–18133 . 1994 . 10.1016/S0021-9258(17)32426-2 . 8027074 . free .
• Fritz CC, Green MR . HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs . Curr. Biol. . 6 . 7 . 848–854 . 1997 . 8805303 . 10.1016/S0960-9822(02)00608-5 . 16705807 . free .
• Zimmermann B, Chiorini JA, Ma Y, etal . PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I . J. Biol. Chem. . 274 . 9 . 5370–5378 . 1999 . 10026146 . 10.1074/jbc.274.9.5370 . free .
• Yu J, Yu L, Chen Z, etal . Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors . Brain Res. Mol. Brain Res. . 99 . 2 . 145–149 . 2002 . 11978406 . 10.1016/S0169-328X(02)00104-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gassel M, Breitenlechner CB, Rüger P, etal . Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT) . J. Mol. Biol. . 329 . 5 . 1021–1034 . 2003 . 12798691 . 10.1016/S0022-2836(03)00518-7 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Olsen SR, Uhler MD . Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor . Mol Endocrinol . 5 . 9 . 1246–1256 . Feb 1992 . 1770951 . 10.1210/mend-5-9-1246 . free .
2. Web site: Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha.