PKD domain explained

PKD (Polycystic Kidney Disease) domain was first identified in the polycystic kidney disease protein, polycystin-1 (PKD1 gene), and contains an Ig-like fold consisting of a beta-sandwich of seven strands in two sheets with a Greek key topology, although some members have additional strands.^[1] Polycystin-1 is a large cell-surface glycoprotein involved in adhesive protein–protein and protein–carbohydrate interactions; however it is not clear if the PKD domain mediates any of these interactions.

PKD domains are also found in other proteins, usually in the extracellular parts of proteins involved in interactions with other proteins. For example, domains with a PKD-type fold are found in archaeal S-layer proteins that protect the cell from extreme environments,^[2] and in the human receptor SorCS2.^[3]

Human proteins containing this domain

GPNMB

PKD1; PKD1L1; PMEL; SORCS1; SORCS2; SORCS3

Notes and References

1. Bycroft M, Bateman A, Clarke J, Hamill SJ, Sandford R, Thomas RL, Chothia C . The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease . EMBO J. . 18 . 2 . 297–305 . 1999 . 9889186 . 10.1093/emboj/18.2.297 . 1171124.
2. Joachimiak A, Springer TA, Zhang RG, Wang JH, Liu JH, Jing H, Takagi J, Lindgren S . Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins . Structure . 10 . 10 . 1453–1464 . 2002 . 12377130 . 10.1016/S0969-2126(02)00840-7. free .
3. Hermans-Borgmeyer I, Hampe W, Schaller HC, Rezgaoui M . The genes for the human VPS10 domain-containing receptors are large and contain many small exons . Hum. Genet. . 108 . 6 . 529–36. 2001 . 11499680 . 10.1007/s004390100504. 23375354 .