PJA2 explained

E3 ubiquitin-protein ligase Praja2 is an enzyme that in humans is encoded by the PJA2 gene.^[1]

Interactions

PJA2 has been shown to interact with UBE2D2.^[2]

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions . Genome Research . 14 . 9 . 1711–8 . September 2004 . 15342556 . 515316 . 10.1101/gr.2435604 .
• Yu P, Chen Y, Tagle DA, Cai T . PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain . Genomics . 79 . 6 . 869–74 . June 2002 . 12036302 . 10.1006/geno.2002.6770 .
• Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K . A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1 . The Journal of Biological Chemistry . 277 . 25 . 22541–6 . June 2002 . 11959851 . 10.1074/jbc.M109728200 . free .
• Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 4 . 5 . 307–13 . October 1997 . 9455477 . 10.1093/dnares/4.5.307 . free .
• Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, Mezey E, Pavan WJ, Mishra B . Praja1, a novel gene encoding a RING-H2 motif in mouse development . Oncogene . 15 . 19 . 2361–8 . November 1997 . 9393880 . 10.1038/sj.onc.1201405 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Nakayama M, Miyake T, Gahara Y, Ohara O, Kitamura T . A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse . The Journal of Neuroscience . 15 . 7 Pt 2 . 5238–48 . July 1995 . 7623148 . 10.1523/JNEUROSCI.15-07-05238.1995. 6577874 .

Notes and References

1. Web site: Entrez Gene: PJA2 praja 2, RING-H2 motif containing.
2. Yu P, Chen Y, Tagle DA, Cai T . PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain . Genomics . 79 . 6 . 869–74 . June 2002 . 12036302 . 10.1006/geno.2002.6770 .