PITPNM1 explained

Membrane-associated phosphatidylinositol transfer protein 1 is a protein that in humans is encoded by the PITPNM1 gene.^{[1] [2]}

Function

PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM]

Interactions

PITPNM1 has been shown to interact with PTK2B.^[3]

Further reading

• Vihtelic TS, Hyde DR, O'Tousa JE . Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene . Genetics . 127 . 4 . 761–8 . 1991 . 10.1093/genetics/127.4.761 . 1903119 . 1204403 .
• Aikawa Y, Hara H, Watanabe T . Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene . Biochem. Biophys. Res. Commun. . 236 . 3 . 559–64 . 1997 . 9245688 . 10.1006/bbrc.1997.7009 .
• Tian D. Litvak V. Toledo-Rodriguez M. Carmon S. Lev. S. Sima Lev . Nir2, a novel regulator of cell morphogenesis . Mol. Cell. Biol. . 22 . 8 . 2650–62 . 2002 . 11909959 . 133726 . 10.1128/MCB.22.8.2650-2662.2002 .
• Litvak V. Tian D. Carmon S. Lev. S. Sima Lev . Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis . Mol. Cell. Biol. . 22 . 14 . 5064–75 . 2002 . 12077336 . 139767 . 10.1128/MCB.22.14.5064-5075.2002 .
• Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S . Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain . Curr. Biol. . 12 . 17 . 1513–8 . 2002 . 12225667 . 10.1016/S0960-9822(02)01107-7 . 5639384 . free . 2002CBio...12.1513L .
• Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S . Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion . Mol. Cell . 14 . 3 . 319–30 . 2004 . 15125835 . 10.1016/S1097-2765(04)00214-X . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Amarilio R, Ramachandran S, Sabanay H, Lev S . Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction . J. Biol. Chem. . 280 . 7 . 5934–44 . 2005 . 15545272 . 10.1074/jbc.M409566200 . free .
• Ocaka L, Spalluto C, Wilson DI, Hunt DM, Halford S . Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3 . Cytogenet. Genome Res. . 108 . 4 . 293–302 . 2005 . 15627748 . 10.1159/000081519 . 20792950 .
• Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S . Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function . Nat. Cell Biol. . 7 . 3 . 225–34 . 2005 . 15723057 . 10.1038/ncb1221 . 5881790 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Burgis NE, Cunningham RP . Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase . J. Biol. Chem. . 282 . 6 . 3531–8 . 2007 . 17090528 . 10.1074/jbc.M608708200 . free .

Notes and References

1. Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S . A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms . Genes Funct. . 1 . 3 . 205–13 . 1997 . 9680295 . 10.1046/j.1365-4624.1997.00015.x .
2. Web site: Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1.
3. Lev S. Hernandez J. Martinez R. Chen A. Plowman G. Schlessinger J. Sima Lev. Joseph Schlessinger . Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein . Mol. Cell. Biol. . 19 . 3 . 2278–88 . Mar 1999 . 10022914 . 84020 . 10.1128/mcb.19.3.2278.