PIP5K1C explained
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma is an enzyme that in humans is encoded by the PIP5K1C gene.[1] [2]
This gene encodes a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.[2]
Further reading
- Niiro H, Clark EA . Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. . Immunity . 19 . 5 . 637–40 . 2003 . 14614850 . 10.1016/S1074-7613(03)00303-0 . free .
- Carpenter CL . Btk-dependent regulation of phosphoinositide synthesis. . Biochem. Soc. Trans. . 32 . Pt 2 . 326–9 . 2004 . 15046600 . 10.1042/BST0320326 .
- Nagase T, Ishikawa K, Miyajima N, etal . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. . DNA Res. . 5 . 1 . 31–9 . 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
- Gotthardt M, Trommsdorff M, Nevitt MF, etal . Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. . J. Biol. Chem. . 275 . 33 . 25616–24 . 2000 . 10827173 . 10.1074/jbc.M000955200 . free .
- Wenk MR, Pellegrini L, Klenchin VA, etal . PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse. . Neuron . 32 . 1 . 79–88 . 2001 . 11604140 . 10.1016/S0896-6273(01)00456-1 . 9739320 . free .
- Di Paolo G, Pellegrini L, Letinic K, etal . Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. . Nature . 420 . 6911 . 85–9 . 2002 . 12422219 . 10.1038/nature01147 . 2002Natur.420...85D . 1746983 .
- Ling K, Doughman RL, Firestone AJ, etal . Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. . Nature . 420 . 6911 . 89–93 . 2002 . 12422220 . 10.1038/nature01082 . 2002Natur.420...89L . 4301885 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Doughman RL, Firestone AJ, Wojtasiak ML, etal . Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling. . J. Biol. Chem. . 278 . 25 . 23036–45 . 2003 . 12682053 . 10.1074/jbc.M211397200 . free .
- Krauss M, Kinuta M, Wenk MR, etal . ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. . J. Cell Biol. . 162 . 1 . 113–24 . 2003 . 12847086 . 10.1083/jcb.200301006 . 2172713 .
- Chang JD, Field SJ, Rameh LE, etal . Identification and characterization of a phosphoinositide phosphate kinase homolog. . J. Biol. Chem. . 279 . 12 . 11672–9 . 2004 . 14701839 . 10.1074/jbc.M309721200 . free .
- Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
- Wang YJ, Li WH, Wang J, etal . Critical role of PIP5KI87 in InsP3-mediated Ca(2+) signaling. . J. Cell Biol. . 167 . 6 . 1005–10 . 2005 . 15611330 . 10.1083/jcb.200408008 . 2172614.
- Bairstow SF, Ling K, Su X, etal . Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis. . J. Biol. Chem. . 281 . 29 . 20632–42 . 2006 . 16707488 . 10.1074/jbc.M601465200 . free .
- Krauss M, Kukhtina V, Pechstein A, Haucke V . Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 32 . 11934–9 . 2006 . 16880396 . 10.1073/pnas.0510306103 . 1567676 . 2006PNAS..10311934K . free .
- Auvinen E, Kivi N, Vaheri A . Regulation of ezrin localization by Rac1 and PIPK in human epithelial cells. . Exp. Cell Res. . 313 . 4 . 824–33 . 2007 . 17229424 . 10.1016/j.yexcr.2006.12.002 .
- Ling K, Bairstow SF, Carbonara C, etal . Type Igamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin. . J. Cell Biol. . 176 . 3 . 343–53 . 2007 . 17261850 . 10.1083/jcb.200606023 . 2063960 .
Notes and References
- Ishihara H, Shibasaki Y, Kizuki N, Wada T, Yazaki Y, Asano T, Oka Y . Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family . J Biol Chem . 273 . 15 . 8741–8 . May 1998 . 9535851 . 10.1074/jbc.273.15.8741 . free .
- Web site: Entrez Gene: PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma.