PIP5K1A explained

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.^{[1] [2] [3]}

Further reading

• Honda A, Nogami M, Yokozeki T, etal . Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. . Cell . 99 . 5 . 521–32 . 1999 . 10589680 . 10.1016/S0092-8674(00)81540-8 . 10031591 . free .
• Jones DH, Morris JB, Morgan CP, etal . Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment. . J. Biol. Chem. . 275 . 18 . 13962–6 . 2000 . 10747863 . 10.1074/jbc.C901019199 . free .
• Divecha N, Roefs M, Halstead JR, etal . Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. . EMBO J. . 19 . 20 . 5440–9 . 2000 . 11032811 . 10.1093/emboj/19.20.5440 . 314009 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Doughman RL, Firestone AJ, Wojtasiak ML, etal . Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling. . J. Biol. Chem. . 278 . 25 . 23036–45 . 2003 . 12682053 . 10.1074/jbc.M211397200 . free .
• Chang JD, Field SJ, Rameh LE, etal . Identification and characterization of a phosphoinositide phosphate kinase homolog. . J. Biol. Chem. . 279 . 12 . 11672–9 . 2004 . 14701839 . 10.1074/jbc.M309721200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kisseleva M, Feng Y, Ward M, etal . The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. . Mol. Cell. Biol. . 25 . 10 . 3956–66 . 2005 . 15870270 . 10.1128/MCB.25.10.3956-3966.2005 . 1087706 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Halstead JR, van Rheenen J, Snel MH, etal . A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. . Curr. Biol. . 16 . 18 . 1850–6 . 2006 . 16979564 . 10.1016/j.cub.2006.07.066 . 15282445 . free .
• Im YJ, Perera IY, Brglez I, etal . Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum. . Plant Cell . 19 . 5 . 1603–16 . 2007 . 17496116 . 10.1105/tpc.107.051367 . 1913725 .

Notes and References

1. Loijens JC, Anderson RA . Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family . J Biol Chem . 271 . 51 . 32937–43 . Jan 1997 . 8955136 . 10.1074/jbc.271.51.32937 . free .
2. Xie Y, Zhu L, Zhao G . Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization . Cytogenet Cell Genet . 88 . 3–4 . 197–9 . Jun 2000 . 10828584 . 10.1159/000015545 . 45527362 .
3. Web site: Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha.