PIP4K2B explained

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.^{[1] [2] [3] [4]}

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol 4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.^[5]

Interactions

PIP4K2B has been shown to interact with TNFRSF1A. In addition, PIP4K2B has been shown to interact with PIP4K2A and may modulate the cellular localisation of PIP4K2A.^[6]

Structure

The structure of PIP4K2B has been determined through X-ray crystallography.^[7]

Further reading

• Niiro H, Clark EA . Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. . Immunity . 19 . 5 . 637–40 . 2003 . 14614850 . 10.1016/S1074-7613(03)00303-0 . free .
• Carpenter CL . Btk-dependent regulation of phosphoinositide synthesis. . Biochem. Soc. Trans. . 32 . Pt 2 . 326–9 . 2004 . 15046600 . 10.1042/BST0320326 .
• Rao VD, Misra S, Boronenkov IV, etal . Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. . Cell . 94 . 6 . 829–39 . 1998 . 9753329 . 10.1016/S0092-8674(00)81741-9 . 18221569 . free .
• Boronenkov IV, Loijens JC, Umeda M, Anderson RA . Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. . Mol. Biol. Cell . 9 . 12 . 3547–60 . 1999 . 9843587 . 10.1091/mbc.9.12.3547. 25675 .
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, etal . NotI flanking sequences: a tool for gene discovery and verification of the human genome. . Nucleic Acids Res. . 30 . 14 . 3163–70 . 2002 . 12136098 . 10.1093/nar/gkf428 . 135748 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Richardson JP, Wang M, Clarke JH, etal . Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation. . Cell. Signal. . 19 . 6 . 1309–14 . 2007 . 17303380 . 10.1016/j.cellsig.2007.01.010 . 1868964 .

Notes and References

1. Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV . A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase . J Biol Chem . 272 . 9 . 5861–70 . Apr 1997 . 9038203 . 10.1074/jbc.272.9.5861 . free .
2. Luoh SW, Venkatesan N, Tripathi R . Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage . Oncogene . 23 . 7 . 1354–63 . Feb 2004 . 14691457 . 10.1038/sj.onc.1207251 . free .
3. Rameh LE, Tolias KF, Duckworth BC, Cantley LC . A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate . Nature . 390 . 6656 . 192–6 . Nov 1997 . 9367159 . 10.1038/36621 . 1997Natur.390..192R . 4403301 .
4. Web site: Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta.
5. Web site: Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta.
6. Bultsma. Yvette. Keune. Willem-Jan. Divecha. Nullin. 2010-09-01. PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα. Biochemical Journal. en. 430. 2. 223–235. 10.1042/bj20100341. 0264-6021. 20583997.
7. Rao. Vibha D. Misra. Saurav. Boronenkov. Igor V. Anderson. Richard A. Hurley. James H. Structure of Type IIβ Phosphatidylinositol Phosphate Kinase. Cell. 94. 6. 829–839. 10.1016/s0092-8674(00)81741-9. 9753329. 1998. 18221569. free.