PIK3R5 explained

Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.^{[1] [2]}

Interactions

PIK3R5 has been shown to interact with PIK3CG.

Further reading

• Johnson C, Marriott SJ, Levy LS . Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival . Oncogene . 26 . 49 . 7049–57 . 2007 . 17486067 . 10.1038/sj.onc.1210504 . free .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Suire S . p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma . Curr. Biol. . 15 . 6 . 566–70 . 2005 . 15797027 . 10.1016/j.cub.2005.02.020 . Coadwell J . Ferguson GJ . Davidson . Keith . Hawkins . Phillip . Stephens . Len . 12255918 . free. 2005CBio...15..566S .
• Voigt P, Brock C, Nürnberg B, Schaefer M . Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma . J. Biol. Chem. . 280 . 6 . 5121–7 . 2005 . 15611065 . 10.1074/jbc.M413104200 . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Metjian A, Roll RL, Ma AD, Abrams CS . Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus . J. Biol. Chem. . 274 . 39 . 27943–7 . 1999 . 10488142 . 10.1074/jbc.274.39.27943 . free .
• Krugmann S, Hawkins PT, Pryer N, Braselmann S . Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits . J. Biol. Chem. . 274 . 24 . 17152–8 . 1999 . 10358071 . 10.1074/jbc.274.24.17152 . free .

Notes and References

1. Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nurnberg B . Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma . J Cell Biol . 160 . 1 . 89–99 . Jan 2003 . 12507995 . 2172741 . 10.1083/jcb.200210115 .
2. Web site: Entrez Gene: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5, p101.