PIK3R3 explained

Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.^{[1] [2]}

Interactions

PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor,^[3] IRS1^{[3] [4]} and Retinoblastoma protein.^[5]

Further reading

• Pons S, Asano T, Glasheen E, etal . The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase . Mol. Cell. Biol. . 15 . 8 . 4453–65 . 1995 . 7542745 . 10.1128/MCB.15.8.4453. 230685 .
• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Tuscano JM, Engel P, Tedder TF, etal . Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22 . Eur. J. Immunol. . 26 . 6 . 1246–52 . 1996 . 8647200 . 10.1002/eji.1830260610 . 29471624 .
• Takahashi-Tezuka M, Hibi M, Fujitani Y, etal . Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK . Oncogene . 14 . 19 . 2273–82 . 1997 . 9178903 . 10.1038/sj.onc.1201071 . free .
• Mothe I, Delahaye L, Filloux C, etal . Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins . Mol. Endocrinol. . 11 . 13 . 1911–23 . 1998 . 9415396 . 10.1210/mend.11.13.0029 . free .
• Xia X, Serrero G . Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation . Biochem. J. . 341 . 3. 831–7 . 1999 . 10417350 . 10.1042/0264-6021:3410831 . 1220424 .
• Inukai K, Funaki M, Anai M, etal . Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations . FEBS Lett. . 490 . 1–2 . 32–8 . 2001 . 11172806 . 10.1016/S0014-5793(01)02132-9 . free .
• Hafizi S, Alindri F, Karlsson R, Dahlbäck B . Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin . Biochem. Biophys. Res. Commun. . 299 . 5 . 793–800 . 2003 . 12470648 . 10.1016/S0006-291X(02)02718-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Xia X, Cheng A, Akinmade D, Hamburger AW . The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest . Mol. Cell. Biol. . 23 . 5 . 1717–25 . 2003 . 12588990 . 10.1128/MCB.23.5.1717-1725.2003 . 151709 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Soroceanu L, Kharbanda S, Chen R, etal . Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma . Proc. Natl. Acad. Sci. U.S.A. . 104 . 9 . 3466–71 . 2007 . 17360667 . 10.1073/pnas.0611271104 . 1802005 . 2007PNAS..104.3466S . free .
• Kallin A, Johannessen LE, Cani PD, etal . SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma . J. Lipid Res. . 48 . 7 . 1628–36 . 2007 . 17452746 . 10.1194/jlr.M700136-JLR200 . free .

Notes and References

1. Dey BR, Furlanetto RW, Nissley SP . Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor . Gene . 209 . 1–2 . 175–83 . May 1998 . 9524259 . 10.1016/S0378-1119(98)00045-6 . free .
2. Web site: Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma).
3. 10.1210/mend.11.13.0029 . Mothe . I . Delahaye L . Filloux C . Pons S . White M F . Van Obberghen E . Dec 1997 . Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins . Mol. Endocrinol. . 11 . 13 . 1911–23 . 0888-8809. 9415396 . free .
4. Xia . X . Serrero G . Aug 1999 . Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation . Biochem. J. . 341 . 3. 831–7 . 0264-6021. 10417350 . 1220424 . 10.1042/0264-6021:3410831.
5. 10.1128/MCB.23.5.1717-1725.2003 . Xia . Xianmin . Cheng Aiwu . Akinmade Damilola . Hamburger Anne W . Mar 2003 . The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest . Mol. Cell. Biol. . 23 . 5 . 1717–25 . 0270-7306. 12588990 . 151709 .