PIK3C2G explained

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene.^{[1] [2]}

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.

Further reading

• Lee C . Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways . J. Leukoc. Biol. . 74 . 5 . 676–82 . 2004 . 12960231 . 10.1189/jlb.0503206 . vanc. Liu QH . Tomkowicz B . 3 . Yi . Y . Freedman . BD . Collman . RG . 11362623 . free.
• Milani D . Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells . J. Biol. Chem. . 271 . 38 . 22961–4 . 1996 . 8798481 . 10.1074/jbc.271.38.22961 . vanc. Mazzoni M . Borgatti P . 3 . Zauli . G . Cantley . L . Capitani . S . free .
• Mazerolles F, Barbat C, Fischer A . Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity . Eur. J. Immunol. . 27 . 9 . 2457–65 . 1997 . 9341793 . 10.1002/eji.1830270946 . 33397908 .
• Borgatti P . Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells . Eur. J. Immunol. . 27 . 11 . 2805–11 . 1998 . 9394803 . 10.1002/eji.1830271110 . vanc. Zauli G . Colamussi ML . 3 . Gibellini . Davide . Previati . Maurizio . Cantley . Lewis L. . Capitani . Silvano . 6303471 .
• Borgatti P, Zauli G, Cantley LC, Capitani S . Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells . Biochem. Biophys. Res. Commun. . 242 . 2 . 332–7 . 1998 . 9446795 . 10.1006/bbrc.1997.7877 .
• Misawa H . Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain . Biochem. Biophys. Res. Commun. . 244 . 2 . 531–9 . 1998 . 9514948 . 10.1006/bbrc.1998.8294 . vanc. Ohtsubo M . Copeland NG . 3 . Gilbert . Debra J. . Jenkins . Nancy A. . Yoshimura . Akihiko .
• Ono F . A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration . J. Biol. Chem. . 273 . 13 . 7731–6 . 1998 . 9516481 . 10.1074/jbc.273.13.7731 . vanc. Nakagawa T . Saito S . 3 . Owada . Y . Sakagami . H . Goto . K . Suzuki . M . Matsuno . S . Kondo . H . free .
• Milani D . HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells . AIDS . 12 . 11 . 1275–84 . 1998 . 9708406 . 10.1097/00002030-199811000-00008 . vanc. Mazzoni M . Zauli G . 3 . Mischiati . Carlo . Gibellini . Davide . Giacca . Mauro . Capitani . Silvano . 25758704 . free .
• Jauliac S . Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity . Eur. J. Immunol. . 28 . 10 . 3183–91 . 1998 . 9808187 . 10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A . vanc. Mazerolles F . Jabado N . 3 . Pallier . Annaïck . Bernard . Frédéric . Peake . Jane . Fischer . Alain . Hivroz . Claire . free .
• Park IW, Wang JF, Groopman JE . HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes . Blood . 97 . 2 . 352–8 . 2001 . 11154208 . 10.1182/blood.V97.2.352 . free .
• Zauli G . HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway . FASEB J. . 15 . 2 . 483–91 . 2001 . 11156964 . 10.1096/fj.00-0354com . vanc. Milani D . Mirandola P . 3 . Mazzoni . M . Secchiero . P . Miscia . S . Capitani . S . free . 26315564 .
• Deregibus MC . HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells . J. Biol. Chem. . 277 . 28 . 25195–202 . 2002 . 11994280 . 10.1074/jbc.M200921200 . vanc. Cantaluppi V . Doublier S . 3 . Brizzi . MF . Deambrosis . I . Albini . A . Camussi . G . free .
• Cook JA, August A, Henderson AJ . Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism . J. Immunol. . 169 . 1 . 254–60 . 2002 . 12077252 . 10.4049/jimmunol.169.1.254. free .
• François F, Klotman ME . Phosphatidylinositol 3-Kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages . J. Virol. . 77 . 4 . 2539–49 . 2003 . 12551992 . 10.1128/JVI.77.4.2539-2549.2003 . 141101 .
• Khan NA, Di Cello F, Nath A, Kim KS . Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells . J. Neurovirol. . 9 . 6 . 584–93 . 2004 . 14602571 . 10.1080/jnv.9.6.584.593 .
• Langford D . Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120 . BMC Neuroscience . 6 . 8 . 2006 . 15689238 . 10.1186/1471-2202-6-8 . 549045 . vanc. Hurford R . Hashimoto M . 3 . Digicaylioglu . Murat . Masliah . Eliezer . free .
• Lee C, Tomkowicz B, Freedman BD, Collman RG . HIV-1 gp120-induced TNF- production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways. . J. Leukoc. Biol. . 78 . 4 . 1016–23 . 2006 . 16081599 . 10.1189/jlb.0105056 . 7628860 . free .
• Anand AR, Ganju RK . HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45 . J. Biol. Chem. . 281 . 18 . 12289–99 . 2006 . 16524887 . 10.1074/jbc.M511786200 . free .

Notes and References

1. Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ . cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12 . Genomics . 54 . 3 . 569–74 . Feb 1999 . 9878262 . 10.1006/geno.1998.5621 .
2. Web site: Entrez Gene: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide.