PIGH explained

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene.^{[1] [2]} The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.^[3]

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.

Interactions

PIGH has been shown to interact with PIGQ.^[4]

Further reading

• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Watanabe R, Inoue N, Westfall B, etal . The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 . EMBO J. . 17 . 4 . 877–85 . 1998 . 9463366 . 10.1093/emboj/17.4.877 . 1170437 .
• Watanabe R, Kinoshita T, Masaki R, etal . PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum . J. Biol. Chem. . 271 . 43 . 26868–75 . 1996 . 8900170 . 10.1074/jbc.271.43.26868 . free .
• Kamitani T, Chang HM, Rollins C, etal . Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone . J. Biol. Chem. . 268 . 28 . 20733–6 . 1993 . 10.1016/S0021-9258(19)36842-5 . 8407896 . free .

Notes and References

1. Ware RE, Howard TA, Kamitani T, Change HM, Yeh ET, Seldin MF . Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria . Blood . 83 . 12 . 3753–7 . Jul 1994 . 10.1182/blood.V83.12.3753.3753 . 8204896 . free .
2. Web site: Entrez Gene: PIGH phosphatidylinositol glycan anchor biosynthesis, class H.
3. Web site: AceView: Homo sapiens gene PIGH. AceView. National Library of Medicine. 24 April 2011.
4. Watanabe . R . Inoue N . Westfall B . Taron C H . Orlean P . Takeda J . Kinoshita T . Feb 1998 . The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 . EMBO J. . 17 . 4 . 877–85 . ENGLAND. 0261-4189. 9463366 . 10.1093/emboj/17.4.877 . 1170437 .