PIBF1 explained

Progesterone-induced-blocking factor 1 is a protein that in humans is encoded by the PIBF1 gene.^{[1] [2]} It has been shown to localize to the centrosome^[3] and has also been named CEP90.^[4]

Further reading

• Szekeres-Bartho J, Barakonyi A, Par G . Progesterone as an immunomodulatory molecule. . Int. Immunopharmacol. . 1 . 6 . 1037–48 . 2001 . 11407300 . 10.1016/S1567-5769(01)00035-2 . etal.
• Szekeres-Bartho J, Varga P, Pejtsik B . ELISA test for the detection of an immunological blocking factor in human pregnancy serum. . J. Reprod. Immunol. . 16 . 1 . 19–29 . 1990 . 2600930 . 10.1016/0165-0378(89)90003-X .
• Szekeres-Bartho J, Faust Z, Varga P . The expression of a progesterone-induced immunomodulatory protein in pregnancy lymphocytes. . Am. J. Reprod. Immunol. . 34 . 6 . 342–8 . 1996 . 8607938 . 10.1111/j.1600-0897.1995.tb00962.x. 6397686 .
• Check JH, Arwitz M, Gross J . Lymphocyte immunotherapy (LI) increases serum levels of progesterone induced blocking factor (PIBF). . Am. J. Reprod. Immunol. . 37 . 1 . 17–20 . 1997 . 9138449 . 10.1111/j.1600-0897.1997.tb00188.x. 19773974 . etal.
• Check JH, Arwitz M, Gross J . Evidence that the expression of progesterone-induced blocking factor by maternal T-lymphocytes is positively correlated with conception. . Am. J. Reprod. Immunol. . 38 . 1 . 6–8 . 1997 . 9266004 . 10.1111/j.1600-0897.1997.tb00269.x. 26240194 . etal.
• Harrington JJ, Sherf B, Rundlett S . Creation of genome-wide protein expression libraries using random activation of gene expression. . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . 25064683 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Polgar B, Kispal G, Lachmann M . Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor. . J. Immunol. . 171 . 11 . 5956–63 . 2004 . 14634107 . 10.4049/jimmunol.171.11.5956. etal. free .
• Dunham A, Matthews LH, Burton J . The DNA sequence and analysis of human chromosome 13. . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . 2004Natur.428..522D . etal.
• Polgár B, Nagy E, Mikó E . Urinary progesterone-induced blocking factor concentration is related to pregnancy outcome. . Biol. Reprod. . 71 . 5 . 1699–705 . 2005 . 15269099 . 10.1095/biolreprod.104.030437 . etal. free .
• Lachmann M, Gelbmann D, Kálmán E . PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome. . Int. J. Cancer . 112 . 1 . 51–60 . 2004 . 15305375 . 10.1002/ijc.20326 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Kozma N, Halasz M, Palkovics T, Szekeres-Bartho J . The progesterone-induced blocking factor modulates the balance of PKC and intracellular Ca. . Am. J. Reprod. Immunol. . 55 . 2 . 122–9 . 2006 . 16433831 . 10.1111/j.1600-0897.2005.00337.x . 32668565 .

Notes and References

1. Rozenblum E, Vahteristo P, Sandberg T, Bergthorsson JT, Syrjakoski K, Weaver D, Haraldsson K, Johannsdottir HK, Vehmanen P, Nigam S, Golberger N, Robbins C, Pak E, Dutra A, Gillander E, Stephan DA, Bailey-Wilson J, Juo SH, Kainu T, Arason A, Barkardottir RB, Nevanlinna H, Borg A, Kallioniemi OP . A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes . Hum Genet . 110 . 2 . 111–21 . Apr 2002 . 11935316 . 10.1007/s00439-001-0646-6 . 21371347 .
2. Web site: Entrez Gene: C13orf24 chromosome 13 open reading frame 24.
3. Lachmann M, Gelbmann D, Kálmán E . PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome. . Int. J. Cancer . 112 . 1 . 51–60 . 2004 . 15305375 . 10.1002/ijc.20326 . etal. free .
4. Kim . K. . Rhee . K. . The pericentriolar satellite protein CEP90 is crucial for integrity of the mitotic spindle pole . Journal of Cell Science . 124 . Pt 3 . 338–347 . 2011 . 21224392 . 10.1242/jcs.078329. 12306606 .