Protein inhibitor of activated STAT2 explained

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.^{[1] [2] [3]}

Interactions

Protein inhibitor of activated STAT2 has been shown to interact with:

• Androgen receptor,^{[4] [5]}
• DNMT3A,^[6]
• PARK7,^[7] and
• UBE2I.^{[8] [9]}

Further reading

• Cookson MR . Pathways to Parkinsonism . Neuron . 37 . 1 . 7–10 . 2003 . 12526767 . 10.1016/S0896-6273(02)01166-2 . 14513509 . free .
• Moilanen AM, Karvonen U, Poukka H, Yan W, Toppari J, Jänne OA, Palvimo JJ . A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins . J. Biol. Chem. . 274 . 6 . 3700–4 . 1999 . 9920921 . 10.1074/jbc.274.6.3700 . free.
• Minty A, Dumont X, Kaghad M, Caput D . Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif . J. Biol. Chem. . 275 . 46 . 36316–23 . 2000 . 10961991 . 10.1074/jbc.M004293200 . free .
• Kotaja N, Aittomäki S, Silvennoinen O, Palvimo JJ, Jänne OA . ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation . Mol. Endocrinol. . 14 . 12 . 1986–2000 . 2001 . 11117529 . 10.1210/mend.14.12.0569 . free .
• Gross M, Liu B, Tan J, French FS, Carey M, Shuai K . Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells . Oncogene . 20 . 29 . 3880–7 . 2001 . 11439351 . 10.1038/sj.onc.1204489 . 12895068 .
• Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H . DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor . J. Biol. Chem. . 276 . 40 . 37556–63 . 2001 . 11477070 . 10.1074/jbc.M101730200 . free .
• Schmidt D, Müller S . Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity . Proc. Natl. Acad. Sci. U.S.A. . 99 . 5 . 2872–7 . 2002 . 11867732 . 122440 . 10.1073/pnas.052559499 . 2002PNAS...99.2872S . free .
• Tan JA, Hall SH, Hamil KG, Grossman G, Petrusz P, French FS . Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators . J. Biol. Chem. . 277 . 19 . 16993–7001 . 2002 . 11877418 . 10.1074/jbc.M109217200 . free .
• Nishida T, Yasuda H . PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription . J. Biol. Chem. . 277 . 44 . 41311–7 . 2003 . 12177000 . 10.1074/jbc.M206741200 . free .
• Tussie-Luna MI, Michel B, Hakre S, Roy AL . The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I . J. Biol. Chem. . 277 . 45 . 43185–93 . 2003 . 12193603 . 10.1074/jbc.M207635200 . free .
• Tussié-Luna MI, Bayarsaihan D, Seto E, Ruddle FH, Roy AL . Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta . Proc. Natl. Acad. Sci. U.S.A. . 99 . 20 . 12807–12 . 2002 . 12239342 . 130541 . 10.1073/pnas.192464499 . 2002PNAS...9912807T . free .
• Miyauchi Y, Yogosawa S, Honda R, Nishida T, Yasuda H . Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes . J. Biol. Chem. . 277 . 51 . 50131–6 . 2003 . 12393906 . 10.1074/jbc.M208319200 . free .
• Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K . PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4 . J. Biol. Chem. . 278 . 24 . 21327–30 . 2003 . 12716907 . 10.1074/jbc.C300119200 . free .
• Ohshima T, Shimotohno K . Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4 . J. Biol. Chem. . 278 . 51 . 50833–42 . 2004 . 14514699 . 10.1074/jbc.M307533200 . free .
• Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J . Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules . Virus Res. . 98 . 1 . 83–91 . 2004 . 14609633 . 10.1016/j.virusres.2003.09.001 .
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .

Notes and References

1. Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K . Inhibition of Stat1-mediated gene activation by PIAS1 . Proc Natl Acad Sci U S A . 95 . 18 . 10626–31 . September 1998 . 9724754 . 27945 . 10.1073/pnas.95.18.10626 . 1998PNAS...9510626L . free .
2. Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R . Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA . Mech Dev . 65 . 1–2 . 3–17 . September 1997 . 9256341 . 10.1016/S0925-4773(97)00032-4 . 11835268 .
3. Web site: Entrez Gene: PIAS2 protein inhibitor of activated STAT, 2.
4. Kotaja N, Aittomäki S, Silvennoinen O, Palvimo JJ, Jänne OA . ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation . Mol. Endocrinol. . 14 . 12 . 1986–2000 . December 2000 . 11117529 . 10.1210/mend.14.12.0569 . free .
5. Moilanen AM, Karvonen U, Poukka H, Yan W, Toppari J, Jänne OA, Palvimo JJ . A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins . J. Biol. Chem. . 274 . 6 . 3700–4 . February 1999 . 9920921 . 10.1074/jbc.274.6.3700. free.
6. Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD . Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription . Nucleic Acids Res. . 2004 . 32 . 2 . 598–610 . 14752048 . 373322 . 10.1093/nar/gkh195 .
7. Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H . DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor . J. Biol. Chem. . 276 . 40 . 37556–63 . October 2001 . 11477070 . 10.1074/jbc.M101730200 . free .
8. Huda Zoghbi. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
9. Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J . Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules . Virus Res. . 98 . 1 . 83–91 . December 2003 . 14609633 . 10.1016/j.virusres.2003.09.001.