PHLPP (gene) explained

PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.^[1]

See also

• PHLPP

Further reading

• Nakajima D, Okazaki N, Yamakawa H, etal . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Nagase T, Ishikawa K, Miyajima N, etal . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. . DNA Res. . 5 . 1 . 31–9 . 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
• Shimizu K, Okada M, Takano A, Nagai K . SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. . FEBS Lett. . 458 . 3 . 363–9 . 2000 . 10570941 . 10.1016/S0014-5793(99)01190-4 . 38044717 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Gao T, Furnari F, Newton AC . PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. . Mol. Cell . 18 . 1 . 13–24 . 2005 . 15808505 . 10.1016/j.molcel.2005.03.008 . free .
• Zhang Y, Wolf-Yadlin A, Ross PL, etal . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . free .
• Nusbaum C, Zody MC, Borowsky ML, etal . DNA sequence and analysis of human chromosome 18. . Nature . 437 . 7058 . 551–5 . 2005 . 16177791 . 10.1038/nature03983 . free . 2005Natur.437..551N .
• Brognard J, Sierecki E, Gao T, Newton AC . PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. . Mol. Cell . 25 . 6 . 917–31 . 2007 . 17386267 . 10.1016/j.molcel.2007.02.017 . free .

Notes and References

1. Web site: Entrez Gene: PHLPP PH domain and leucine rich repeat protein phosphatase.