PHLDB1 explained

Pleckstrin homology-like domain family B member 1 is a protein that in humans is encoded by the PHLDB1 gene.^{[1] [2]}

The first PHLDB1 cDNA was cloned from a rat pituitary cDNA library and named as LL5 after the clone number.^[3]

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . June 2002 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 5 . 3 . 169–76 . June 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
• Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR . Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities . Biochem. J. . 351 . Pt 1 . 19–31 . October 2000 . 11001876 . 1221362 . 10.1042/0264-6021:3510019 .
• Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y . Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta . J. Cell Biol. . 189 . 5 . 901–17 . May 2010 . 20513769 . 2878951 . 10.1083/jcb.200910095 .

Notes and References

1. Katoh M, Katoh M . Identification and characterization of human LL5A gene and mouse Ll5a gene in silico . Int J Oncol . 23 . 5 . 1477–83 . Oct 2003 . 14532993 . 10.3892/ijo.23.5.1477.
2. Web site: Entrez Gene: PHLDB1 pleckstrin homology-like domain, family B, member 1.
3. Levi L, Hanukoglu I, Raikhinstein M, Kohen F, Koch Y . Cloning of LL5, a novel protein encoding cDNA from a rat pituitary library. . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1216 . 2 . 342–4 . 16 November 1993 . 8241284 . 10.1016/0167-4781(93)90171-9 .