PHLDA1 explained

Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.^{[1] [2] [3]}

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.^[3]

Interactions

PHLDA1 has been shown to interact with RPL14,^[4] EIF3D^[4] and PABPC4.^[4]

Further reading

• Reddy PH, Stockburger E, Gillevet P, Tagle DA . Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. . Genomics . 46 . 2 . 174–82 . 1998 . 9417904 . 10.1006/geno.1997.5044 .
• Kuske MD, Johnson JP . Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping. . Cytogenet. Cell Genet. . 89 . 1–2 . 1 . 2000 . 10894922 . 10.1159/000015575 . 84103198 .
• Hinz T, Flindt S, Marx A, etal . Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product . Cell. Signal. . 13 . 5 . 345–52 . 2001 . 11369516 . 10.1016/S0898-6568(01)00141-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hossain GS, van Thienen JV, Werstuck GH, etal . TDAG51 Is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia . J. Biol. Chem. . 278 . 32 . 30317–27 . 2003 . 12738777 . 10.1074/jbc.M212897200 . free .
• Oberg HH, Sipos B, Kalthoff H, etal . Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells . Cell Death Differ. . 11 . 6 . 674–84 . 2005 . 15002043 . 10.1038/sj.cdd.4401407 . free .
• Meier-Noorden M, Flindt S, Kalinke U, Hinz T . A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation . Gene . 338 . 2 . 197–207 . 2004 . 15315823 . 10.1016/j.gene.2004.05.006 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Neef R, Kuske MA, Prols E, Johnson JP . Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation . Cancer Res . 62 . 20 . 5920–9 . Oct 2002 . 12384558 .
2. Toyoshima Y . Karas M . Yakar S . Dupont J . Lee Helman . LeRoith D . TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival . J Biol Chem . 279 . 24 . 25898–904 . Jun 2004 . 15037619 . 10.1074/jbc.M400661200 . free .
3. Web site: Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1.
4. Hinz . T . Flindt S . Marx A . Janssen O . Kabelitz D . May 2001 . Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product . Cell. Signal. . 13 . 5 . 345–52 . England. 0898-6568. 11369516 . 10.1016/S0898-6568(01)00141-3 .