PHF21A explained

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.^{[1] [2]}

Function

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM]^[3]

Interactions

PHF21A has been shown to interact with:

• HDAC1,^[2]
• HMG20B,^{[2] [4]}
• Histone deacetylase 2,^{[2] [4] [5]} and
• RCOR1.^{[2] [4]}

Further reading

• Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y . Regulation of LSD1 histone demethylase activity by its associated factors . Mol. Cell . 19 . 6 . 857–64 . 2005 . 16140033 . 10.1016/j.molcel.2005.08.027 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Hailesellasse Sene K, Porter CJ, Palidwor G, Perez-Iratxeta C, Muro EM, Campbell PA, Rudnicki MA, Andrade-Navarro MA . Gene function in early mouse embryonic stem cell differentiation . BMC Genomics . 8 . 85 . 2007 . 17394647 . 1851713 . 10.1186/1471-2164-8-85 . free .

Notes and References

1. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 6 . 347–55 . 2000 . 11214970 . 10.1093/dnares/7.6.347 . free .
2. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R . A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes . Proc. Natl. Acad. Sci. U.S.A. . 99 . 11 . 7420–5 . May 2002 . 12032298 . 124246 . 10.1073/pnas.112008599 . 2002PNAS...99.7420H . free .
3. Web site: Entrez Gene: PHF21A PHD finger protein 21A.
4. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T . Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression . Biochem. Biophys. Res. Commun. . 322 . 2 . 601–8 . Sep 2004 . 15325272 . 10.1016/j.bbrc.2004.07.163 .
5. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R . A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes . J. Biol. Chem. . 278 . 9 . 7234–9 . Feb 2003 . 12493763 . 10.1074/jbc.M208992200 . free .