PHF1 explained

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.^{[1] [2] [3]}

Function

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.

Further reading

• Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y . Role of hPHF1 in H3K27 methylation and Hox gene silencing . Molecular and Cellular Biology . 28 . 5 . 1862–72 . March 2008 . 18086877 . 2258785 . 10.1128/MCB.01589-07 .
• O'Connell S, Wang L, Robert S, Jones CA, Saint R, Jones RS . Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein . The Journal of Biological Chemistry . 276 . 46 . 43065–73 . November 2001 . 11571280 . 10.1074/jbc.M104294200 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Coulson M, Robert S, Eyre HJ, Saint R . The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster . Genomics . 48 . 3 . 381–3 . March 1998 . 9545646 . 10.1006/geno.1997.5201 .
2. Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A . A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell . Nucleic Acids Research . 36 . 9 . 2939–47 . May 2008 . 18385154 . 2396414 . 10.1093/nar/gkn146 .
3. Web site: Entrez Gene: PHF1 PHD finger protein 1.