PHB2 explained

Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene.^{[1] [2] [3]}

Interactions

PHB2 has been shown to interact with PTMA.^[4]

Further reading

• Martini PG, Katzenellenbogen BS . Modulation of estrogen receptor activity by selective coregulators . J. Steroid Biochem. Mol. Biol. . 85 . 2–5 . 117–22 . 2003 . 12943695 . 10.1016/S0960-0760(03)00207-3 . 32374864 .
• Ansari-Lari MA, Muzny DM, Lu J, etal . A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13 . Genome Res. . 6 . 4 . 314–26 . 1996 . 8723724 . 10.1101/gr.6.4.314 . free .
• Ansari-Lari MA, Shen Y, Muzny DM, etal . Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination . Genome Res. . 7 . 3 . 268–80 . 1997 . 9074930 . 10.1101/gr.7.3.268 . free .
• Montano MM, Ekena K, Delage-Mourroux R, etal . An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens . Proc. Natl. Acad. Sci. U.S.A. . 96 . 12 . 6947–52 . 1999 . 10359819 . 10.1073/pnas.96.12.6947 . 22022 . 1999PNAS...96.6947M . free .
• Hu RM, Han ZG, Song HD, etal . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . 2000PNAS...97.9543H . free .
• Martini PG, Delage-Mourroux R, Kraichely DM, Katzenellenbogen BS . Prothymosin Alpha Selectively Enhances Estrogen Receptor Transcriptional Activity by Interacting with a Repressor of Estrogen Receptor Activity . Mol. Cell. Biol. . 20 . 17 . 6224–32 . 2000 . 10938099 . 10.1128/MCB.20.17.6224-6232.2000 . 86097 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Kurtev V, Margueron R, Kroboth K, etal . Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases . J. Biol. Chem. . 279 . 23 . 24834–43 . 2004 . 15140878 . 10.1074/jbc.M312300200 . free .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Scherer SE, Muzny DM, Buhay CJ, etal . The finished DNA sequence of human chromosome 12 . Nature . 440 . 7082 . 346–51 . 2006 . 16541075 . 10.1038/nature04569 . 2006Natur.440..346S . free .
• Kasashima K, Ohta E, Kagawa Y, Endo H . Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2 . J. Biol. Chem. . 281 . 47 . 36401–10 . 2007 . 17008324 . 10.1074/jbc.M605260200 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Takata H, Matsunaga S, Morimoto A, etal . PHB2 protects sister-chromatid cohesion in mitosis . Curr. Biol. . 17 . 15 . 1356–61 . 2007 . 17656096 . 10.1016/j.cub.2007.07.009 . 18987683 . free . 2007CBio...17.1356T .

Notes and References

1. Coates PJ, Nenutil R, McGregor A, Picksley SM, Crouch DH, Hall PA, Wright EG . Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence . Exp Cell Res . 265 . 2 . 262–73 . Apr 2001 . 11302691 . 10.1006/excr.2001.5166 .
2. Coates PJ, Jamieson DJ, Smart K, Prescott AR, Hall PA . The prohibitin family of mitochondrial proteins regulate replicative lifespan . Curr Biol . 7 . 8 . 607–10 . Oct 1997 . 9259555 . 10.1016/S0960-9822(06)00261-2 . 7153605 . free . 1997CBio....7..607C .
3. Web site: Entrez Gene: PHB2 prohibitin 2.
4. 10.1016/S0960-0760(03)00207-3 . Martini . Paolo G V . Katzenellenbogen Benita S . Jun 2003 . Modulation of estrogen receptor activity by selective coregulators . J. Steroid Biochem. Mol. Biol. . 85 . 2–5 . 117–22 . 0960-0760. 12943695 . 32374864 .