PHACTR3 explained

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.^{[1] [2]}

Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.^[2]

Interactions

PHACTR3 has been shown to interact with PPP1CA.^[3]

Further reading

• Worch S, Fiedler E, Hansmann I, Schlote D . Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human. . Cytogenet. Genome Res. . 115 . 1 . 23–9 . 2006 . 16974080 . 10.1159/000094797 . 38349132 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S . Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure. . J. Biol. Chem. . 278 . 46 . 45611–9 . 2003 . 12925532 . 10.1074/jbc.M305227200 . free .

Notes and References

1. Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P . Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins . Proc Natl Acad Sci U S A . 101 . 18 . 7187–92 . May 2004 . 15107502 . 406487 . 10.1073/pnas.0401673101 . 2004PNAS..101.7187A . free .
2. Web site: Entrez Gene: PHACTR3 phosphatase and actin regulator 3.
3. Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S . Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure . J. Biol. Chem. . 278 . 46 . 45611–9 . Nov 2003 . 12925532 . 10.1074/jbc.M305227200 . free .