PHA-57378 explained

PHA-57378 is a drug which acts as an agonist at serotonin 5-HT₂ receptors,^[1] having a binding affinity of 4.1 nM at the 5-HT_2A subtype and 4.3 nM at 5-HT_2C. It has anxiolytic effects in animal studies.^[2]

See also

• PNU-22394
• PNU-181731
• WAY-470

Notes and References

1. WO . 2000064899 . application . Tetracyclic Azepinoindole Compounds as 5-HT Receptor Ligands . 2 November 2000 . April 20, 2000 . April 23, 1999 . Hester JB, Rogers BN, Jacobsen EJ, Ennis MD, Acker BA, Van der Velde SL, Frank KE . Pharmacia Upjohn Company .
2. Ennis MD, Hoffman RL, Ghazal NB, Olson RM, Knauer CS, Chio CL, Hyslop DK, Campbell JE, Fitzgerald LW, Nichols NF, Svensson KA, McCall RB, Haber CL, Kagey ML, Dinh DM . 6 . 2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists . Bioorganic & Medicinal Chemistry Letters . 13 . 14 . 2369–72 . July 2003 . 12824036 . 10.1016/S0960-894X(03)00403-7 .