Itruvone Explained
| Routes Of Administration: | Intranasal (spray) |
| Cas Number: | 21321-89-1 |
| Pubchem: | 15633961 |
| Chemspiderid: | 18829396 |
| Unii: | 72HML2UK6J |
| Kegg: | D12542 |
| Synonyms: | PH10; PH10A; PH10 NS; Pregn-4-en-20-yn-3-one |
| Iupac Name: | (8S,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| C: | 21 |
| H: | 28 |
| O: | 1 |
| Smiles: | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C#C)CCC4=CC(=O)CC[C@]34C |
| Stdinchi: | 1S/C21H28O/c1-4-14-6-8-18-17-7-5-15-13-16(22)9-11-21(15,3)19(17)10-12-20(14,18)2/h1,13-14,17-19H,5-12H2,2-3H3/t14-,17-,18-,19-,20+,21-/m0/s1 |
| Stdinchikey: | CHOUAXDNNAVGHR-NWSAAYAGSA-N |
Itruvone (; developmental code name PH10), also known as pregn-4-en-20-yn-3-one, is a vomeropherine which is under development by VistaGen Therapeutics as a nasal spray for the treatment of major depressive disorder.[1] [2] [3] [4] [5] [6]
See also
Notes and References
- Web site: PH-10 Nasal Spray . AdisInsight . Springer Nature Switzerland AG .
- Monti L, Liebowitz MR . Neural circuits of anxiolytic and antidepressant pherine molecules . CNS Spectr . 27 . 1 . 66–72 . February 2022 . 33092667 . 10.1017/S109285292000190X . 225053518 . free .
- Web site: VistaGen Therapeutics Acquires Worldwide Rights to Develop and Commercialize PH10, a First-in-Class Intranasally Administered Neuroactive Steroid with Rapid-onset Antidepressant Effects for Major Depressive Disorder Demonstrated in Phase 2a Study :: VistaGen Therapeutics, Inc. (VTGN). VistaGen Therapeutics, Inc.. en. 2019-12-19.
- Web site: October 29, 2018. Health Care Digest: A small biotech goes head first, Gilead's lower tax rate and more. 20 July 2020. www.bizjournals.com. San Francisco Business Times.
- Liebowitz MR, Nicolini H, Monti L, Hanover R . PH 10 may be a new rapidly acting intranasally administered antidepressant. 2013. American Society of Clinical Psychopharmacology (ASCP) Annual Meeting, Miami, FL.
- Web site: Novel intranasal antidepressant shows results after 1 week . Jancin . Bruce . vanc . 2013 . Clinical Psychiatry News . 13 January 2016 .
