Prostaglandin G2 Explained

Prostaglandin G2 is an organic peroxide belonging to the family of prostaglandins.^[1] The compound has been isolated as a solid, although it is usually used in vivo. It quickly converts into prostaglandin H2, a process catalyzed by the enzyme COX.

Prostaglandin G2 is produced from the fatty acid arachidonic acid. The reaction, a double oxygenation, requires the enzyme cyclooxygenase, which inserts two molecules of O₂ into the C-H bonds of the substrate acid.^{[2] [1] [3]}

Notes and References

1. The cyclooxygenase reaction mechanism. Wilfred van der Donk. Tsai Ah-Lim. Kulmacz Richard J.. Biochemistry. 2002. 41. 52. 15451–8. 10.1021/bi026938h. 12501173.
2. 10.1021/cr000068x . Mechanism of Free Radical Oxygenation of Polyunsaturated Fatty Acids by Cyclooxygenases . 2003 . Rouzer . Carol A. . Marnett . Lawrence J. . Chemical Reviews . 103 . 6 . 2239–2304 . 12797830 .
3. Web site: Prostaglandin G2. Santa cruz biotechnology, inc. 27 April 2015.