PFDN4 explained

Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene.^{[1] [2] [3]}

Function

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.

Further reading

• Hartl FU, Hayer-Hartl M . Molecular chaperones in the cytosol: from nascent chain to folded protein . Science . 295 . 5561 . 1852–8 . Mar 2002 . 11884745 . 10.1126/science.1068408 . 2002Sci...295.1852H . 15037639 .
• Hansen WJ, Cowan NJ, Welch WJ . Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins . The Journal of Cell Biology . 145 . 2 . 265–77 . Apr 1999 . 10209023 . 2133115 . 10.1083/jcb.145.2.265 .
• Cowan NJ, Lewis SA . A chaperone with a hydrophilic surface . Nature Structural Biology . 6 . 11 . 990–1 . Nov 1999 . 10542082 . 10.1038/14870 . 22081346 .
• Collins C, Volik S, Kowbel D, Ginzinger D, Ylstra B, Cloutier T, Hawkins T, Predki P, Martin C, Wernick M, Kuo WL, Alberts A, Gray JW . Comprehensive genome sequence analysis of a breast cancer amplicon . Genome Research . 11 . 6 . 1034–42 . Jun 2001 . 11381030 . 311107 . 10.1101/gr.gr1743r.
• Martín-Benito J, Boskovic J, Gómez-Puertas P, Carrascosa JL, Simons CT, Lewis SA, Bartolini F, Cowan NJ, Valpuesta JM . Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT . The EMBO Journal . 21 . 23 . 6377–86 . Dec 2002 . 12456645 . 136944 . 10.1093/emboj/cdf640 .
• Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W . Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI . Science . 302 . 5648 . 1208–12 . Nov 2003 . 14615539 . 10.1126/science.1088401 . 2003Sci...302.1208G . 26836888 .
• Simons CT, Staes A, Rommelaere H, Ampe C, Lewis SA, Cowan NJ . Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding . The Journal of Biological Chemistry . 279 . 6 . 4196–203 . Feb 2004 . 14634002 . 10.1074/jbc.M306053200 . free .

Notes and References

1. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ . Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin . Cell . 93 . 5 . 863–73 . May 1998 . 9630229 . 10.1016/s0092-8674(00)81446-4 . 16011829 . free .
2. Iijima M, Kano Y, Nohno T, Namba M . Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines . Acta Medica Okayama . 50 . 2 . 73–7 . Apr 1996 . 8744932 .
3. Coraboeuf E, Deroubaix E, Hoerter J . Control of ionic permeabilities in normal and ischemic heart . Circulation Research . 38 . 5 Suppl 1 . I92–8 . May 1976 . 5203 .