PF-04479745 explained

PF-04479745 is a research ligand developed by Pfizer. It is related to lorcaserin, and acts as a potent and selective agonist for the 5-HT_2C receptor, with lower affinity and antagonist action at the related 5-HT_2A and 5-HT_2B receptor subtypes.^[1]

Notes and References

1. Storer RI, Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, DePianta RP, Fish PV, Heifetz A, Ho DK, Jessiman AS, McMurray G, de Oliveira CA, Roberts LR, Root JA, Shanmugasundaram V, Shapiro MJ, Skerten M, Westbrook D, Wheeler S, Whitlock GA, Wright J . 6 . Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT_2C) receptor agonists with exquisite functional selectivity over 5-HT_2A and 5-HT_2B receptors . Journal of Medicinal Chemistry . 57 . 12 . 5258–69 . June 2014 . 24878222 . 10.1021/jm5003292 .