PEX26 explained

Peroxisome assembly protein 26 is a protein that in humans is encoded by the PEX26 gene.^{[1] [2] [3]}

Interactions

PEX26 has been shown to interact with PEX1, PEX6^[1] and SUFU.^[4]

Further reading

• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . Dec 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I . A genome annotation-driven approach to cloning the human ORFeome . Genome Biology . 5 . 10 . R84 . 2005 . 15461802 . 545604 . 10.1186/gb-2004-5-10-r84 . free .
• Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP . Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis . Journal of Molecular Biology . 346 . 5 . 1275–86 . Mar 2005 . 15713480 . 10.1016/j.jmb.2005.01.013 .
• Weller S, Cajigas I, Morrell J, Obie C, Steel G, Gould SJ, Valle D . Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis . American Journal of Human Genetics . 76 . 6 . 987–1007 . Jun 2005 . 15858711 . 1196456 . 10.1086/430637 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Furuki S, Tamura S, Matsumoto N, Miyata N, Moser A, Moser HW, Fujiki Y . Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex . The Journal of Biological Chemistry . 281 . 3 . 1317–23 . Jan 2006 . 16257970 . 10.1074/jbc.M510044200 . free .
• Halbach A, Landgraf C, Lorenzen S, Rosenkranz K, Volkmer-Engert R, Erdmann R, Rottensteiner H . Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites . Journal of Cell Science . 119 . Pt 12 . 2508–17 . Jun 2006 . 16763195 . 10.1242/jcs.02979 . 20304149 .
• Tamura S, Yasutake S, Matsumoto N, Fujiki Y . Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p . The Journal of Biological Chemistry . 281 . 38 . 27693–704 . Sep 2006 . 16854980 . 10.1074/jbc.M605159200 . free .

External links

• GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
• OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum

Notes and References

1. Matsumoto N, Tamura S, Fujiki Y . The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes . Nature Cell Biology . 5 . 5 . 454–60 . May 2003 . 12717447 . 10.1038/ncb982 . 2426040 .
2. Matsumoto N, Tamura S, Furuki S, Miyata N, Moser A, Shimozawa N, Moser HW, Suzuki Y, Kondo N, Fujiki Y . Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation . American Journal of Human Genetics . 73 . 2 . 233–46 . Aug 2003 . 12851857 . 1180364 . 10.1086/377004 .
3. Web site: Entrez Gene: PEX26 peroxisome biogenesis factor 26.
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Huda Zoghbi . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .