PEX11B explained

Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene.^{[1] [2]} It is involved in the regulation of peroxisome abundance.^[3]

Interactions

PEX11B has been shown to interact with PEX19.^{[4] [5]}

Related gene problems

• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

Further reading

• Abe I, Fujiki Y . cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p . Biochem. Biophys. Res. Commun. . 252 . 2 . 529–33 . 1998 . 9826565 . 10.1006/bbrc.1998.9684 .
• Sacksteder KA, Jones JM, South ST, etal . Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis . J. Cell Biol. . 148 . 5 . 931–44 . 2000 . 10704444 . 10.1083/jcb.148.5.931 . 2174547 .
• Fransen M, Brees C, Ghys K, etal . Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay . Mol. Cell. Proteomics . 1 . 3 . 243–52 . 2002 . 12096124 . 10.1074/mcp.M100025-MCP200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Li X, Gould SJ . The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11 . J. Biol. Chem. . 278 . 19 . 17012–20 . 2003 . 12618434 . 10.1074/jbc.M212031200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Kobayashi S, Tanaka A, Fujiki Y . Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis . Exp. Cell Res. . 313 . 8 . 1675–86 . 2007 . 17408615 . 10.1016/j.yexcr.2007.02.028 .

Notes and References

1. Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ . Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli . J Biol Chem . 273 . 45 . 29607–14 . December 1998 . 9792670 . 10.1074/jbc.273.45.29607 . free .
2. Web site: Entrez Gene: PEX11B peroxisomal biogenesis factor 11B.
3. Thoms S, Erdmann R . Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation. . FEBS J . 272 . 20 . 5169–81 . October 2005 . 16218949 . 10.1111/j.1742-4658.2005.04939.x . 33237347 .
4. Sacksteder . K A . Jones J M . South S T . Li X . Liu Y . Gould S J . March 2000 . Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis . J. Cell Biol. . 148 . 5 . 931–44 . 0021-9525. 10704444 . 10.1083/jcb.148.5.931 . 2174547 .
5. Fransen . M . Wylin T . Brees C . Mannaerts G P . Van Veldhoven P P . July 2001 . Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences . Mol. Cell. Biol. . 21 . 13 . 4413–24 . 0270-7306. 11390669 . 10.1128/MCB.21.13.4413-4424.2001 . 87101 .