PES1 explained

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.^{[1] [2] [3] [4]}

This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.^[4]

Further reading

• Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Kinoshita Y, Jarell AD, Flaman JM, etal . Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells . J. Biol. Chem. . 276 . 9 . 6656–65 . 2001 . 11071894 . 10.1074/jbc.M008536200 . free .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . free . 2002CBio...12....1A .
• Oeffinger M, Leung A, Lamond A, etal . Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis . RNA . 8 . 5 . 626–36 . 2002 . 12022229 . 10.1017/S1355838202020022 . 1370283 .
• Scherl A, Couté Y, Déon C, etal . Functional Proteomic Analysis of Human Nucleolus . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 10.1091/mbc.E02-05-0271 . 133617 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Lapik YR, Fernandes CJ, Lau LF, Pestov DG . Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis . Mol. Cell . 15 . 1 . 17–29 . 2004 . 15225545 . 10.1016/j.molcel.2004.05.020 . free .
• Maiorana A, Tu X, Cheng G, Baserga R . Role of pescadillo in the transformation and immortalization of mammalian cells . Oncogene . 23 . 42 . 7116–24 . 2004 . 15273728 . 10.1038/sj.onc.1207916 . free .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Killian A, Le Meur N, Sesboüé R, etal . Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability . Oncogene . 23 . 53 . 8597–602 . 2004 . 15467761 . 10.1038/sj.onc.1207845 . 7435460 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Hölzel M, Rohrmoser M, Schlee M, etal . Mammalian WDR12 is a novel member of the Pes1–Bop1 complex and is required for ribosome biogenesis and cell proliferation . J. Cell Biol. . 170 . 3 . 367–78 . 2005 . 16043514 . 10.1083/jcb.200501141 . 2171466 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Allende ML, Amsterdam A, Becker T, Kawakami K, Gaiano N, Hopkins N . Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development . Genes Dev . 10 . 24 . 3141–55 . Jan 1997 . 8985183 . 10.1101/gad.10.24.3141 . free .
2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP. The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . Dec 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . etal. free .
3. Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D . Interdependence of Pes1, Bop1, and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit . Mol Cell Biol . 27 . 10 . 3682–94 . May 2007 . 17353269 . 1899993 . 10.1128/MCB.00172-07 .
4. Web site: Entrez Gene: PES1 pescadillo homolog 1, containing BRCT domain (zebrafish).