PERP explained

p53 apoptosis effector related to PMP-22 is a plasma membrane protein that, in humans, is encoded by the PERP gene.^{[1] [2]}

PERP is a direct transcriptional target of p53, but its transcription can also be regulated by other transcription factors.^[3]

PERP is important for skin development, and loss of PERP is associated with the development and progression of several types of human cancers.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Attardi LD, Reczek EE, Cosmas C, etal . PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. . Genes Dev. . 14 . 6 . 704–718 . 2000 . 10.1101/gad.14.6.704 . 10733530 . 316461 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bonkobara M, Das A, Takao J, etal . Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. . Br. J. Dermatol. . 148 . 4 . 654–664 . 2003 . 12752121 . 10.1046/j.1365-2133.2003.05244.x . 21635573 .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–811 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Ihrie RA, Attardi LD . Perp-etrating p53-dependent apoptosis. . Cell Cycle . 3 . 3 . 267–269 . 2004 . 14726658 . 10.4161/cc.3.3.722. free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–126 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .

Notes and References

1. Hildebrandt T, Preiherr J, Tarbe N, Klostermann S, Van Muijen GN, Weidle UH . Identification of THW, a putative new tumor suppressor gene . Anticancer Res . 20 . 5A . 2801–2809 . Dec 2000 . 11062687 .
2. Web site: Entrez Gene: PERP PERP, TP53 apoptosis effector.
3. Roberts O, Paraoan L . PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP . Biochim Biophys Acta Rev Cancer . 1874 . 1 . Dec 2020 . 188393 . 32679166 . 10.1016/j.bbcan.2020.188393. 220631324 .
4. Roberts O, Paraoan L . PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP . Biochim Biophys Acta Rev Cancer . 1874 . 1 . Dec 2020 . 188393 . 32679166 . 10.1016/j.bbcan.2020.188393. 220631324 .