PEPA (drug) explained

PEPA is a sulfonamide AMPA receptor positive allosteric modulator,[1] [2] which is up to 100 times more potent than aniracetam in vitro.[3] It produces memory-enhancing effects in rats when administered intravenously.[4]

See also

Notes and References

  1. Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K . 6 . Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures . British Journal of Pharmacology . 123 . 7 . 1294–303 . April 1998 . 9579722 . 1565288 . 10.1038/sj.bjp.0701707 .
  2. Sekiguchi M, Nishikawa K, Aoki S, Wada K . A desensitization-selective potentiator of AMPA-type glutamate receptors . British Journal of Pharmacology . 136 . 7 . 1033–41 . August 2002 . 12145103 . 1573432 . 10.1038/sj.bjp.0704804 .
  3. Sekiguchi M, Fleck MW, Mayer ML, Takeo J, Chiba Y, Yamashita S, Wada K . A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide . The Journal of Neuroscience . 17 . 15 . 5760–71 . August 1997 . 9221774 . 6573208 . 10.1523/JNEUROSCI.17-15-05760.1997 .
  4. Sekiguchi M, Yamada K, Jin J, Hachitanda M, Murata Y, Namura S, Kamichi S, Kimura I, Wada K . 6 . The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment . NeuroReport . 12 . 13 . 2947–50 . September 2001 . 11588608 . 10.1097/00001756-200109170-00038 . 42785890 .

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